Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Sinonasal Therapies and Histologic Correlations for Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Indiana University
64 participants
Jul 2, 2025
INTERVENTIONAL
Conditions
Summary
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)
Eligibility
Inclusion Criteria4
- Age 18 or older
- Cystic Fibrosis diagnosis on HEMT
- History of chronic rhinosinusitis
- Using topical nasal irrigations +/- additives (steroids, antibiotics)
Exclusion Criteria8
- Below age of 18 years old
- Cystic Fibrosis patient NOT on highly effective modulator therapy
- Pregnant patients
- Not currently using topical nasal irrigations +/- additives (steroids, antibiotics)
- History of sinonasal or nasopharyngeal tumors
- Active sinonasal infection or pulmonary infection
- Admission to hospital for pulmonary exacerbation within last 3 months
- Oral antibiotics within last one month for upper respiratory or lower respiratory infection
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Interventions
PATIENT WILL STOP USING NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID
PATIENT WILL CONTINUE USING NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06996951