RecruitingNot ApplicableNCT07438912

Mind After Midnight

The Mind After Midnight: Mechanistic Examination of Nocturnal Wakefulness as a Suicide Risk Factor

Sponsor

University of Arizona

Enrollment

90 participants

Start Date

Mar 1, 2026

Study Type

INTERVENTIONAL

Conditions

Suicidal Ideation Sleep Deprivation Sleep Wake Disorders Circadian Rhythm Disorders

Summary

This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure. Participants will be evaluated during late-night wakefulness and under conditions of both higher and lower sleep pressure. The goal of the study is to better understand the biological and behavioral mechanisms that may contribute to elevated suicide risk during nocturnal wakefulness.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria5

Age 18-55 years
History of suicidal ideation within the past 6 months
Habitual bedtime between 9:00 PM and 1:00 AM
Habitual wake time between 6:00 AM and 9:00 AM
Ability to provide informed consent

Exclusion Criteria8

Current suicidal intent requiring immediate clinical intervention
Diagnosis of a primary sleep disorder (e.g., untreated obstructive sleep apnea, narcolepsy)
Bipolar disorder or psychotic disorder
Substance use disorder within the past 3 months
Use of medications that significantly affect sleep or circadian rhythms
Night shift work or transmeridian travel within the past month
Medical or neurological condition that would interfere with participation
Pregnancy

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Interventions

BEHAVIORALSleep Pressure Manipulation

Participants undergo an experimental manipulation of homeostatic sleep pressure involving controlled wakefulness or scheduled awakening during the biological night. Mood, suicidal ideation, impulsivity, and decision-making are assessed during overnight laboratory sessions.