Comparison of Root Canal Desinfection Protocols
Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study
State University of New York at Buffalo
50 participants
Apr 1, 2026
INTERVENTIONAL
Conditions
Summary
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
Eligibility
Inclusion Criteria5
- Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up.
- Molar teeth indicated for endodontic treatment.
- Teeth with intact pulp-chamber walls (no extensive coronal destruction).
- Necrotic pulp confirmed by pulp testing.
- Clinical and radiographic evidence of asymptomatic apical periodontitis.
Exclusion Criteria9
- Immature teeth
- Teeth with calcified or obliterated canals
- Teeth with extensive coronal destruction
- Teeth with previous endodontic treatment
- Symptomatic apical periodontitis
- Teeth with periodontal pockets greater than 4 mm
- Patients who have received systemic antibiotics in the last 3 months
- Patients with a history of diabetes or immune impairment
- Pregnant patients
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Interventions
Desinfection protocol with (LAI): Er,Cr:YSGG laser (2780 nm) delivered with a radial-firing tip.
Endocator: Measures ATP levels (Endoscore and RLU) to rapidly assess bacterial load in less than one minute.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07439614