Effect of Resistance Exercise on Energy Balance and Appetite Regulation in Males and Females
National Taiwan Normal University
30 participants
Dec 1, 2025
INTERVENTIONAL
Conditions
Summary
There is growing evidence that males and females may exhibit different acute responses and long-term adaptations to exercise training. Accordingly, contemporary exercise physiology research increasingly recognizes sex as an important biological variable that may influence appetite regulation and energy balance. This year's project aims to investigate: (1) appetite regulation and energy balance following acute resistance exercise, and (2) potential sex-based differences in appetite regulation and energy balance in response to resistance exercise. Understanding both the overall effects of resistance exercise and sex-related variability in these responses is important for improving the physiological interpretation of exercise-induced changes in appetite and energy balance. Such knowledge may help to reduce heterogeneity in exercise research findings and support the development of more precise, evidence-based exercise prescriptions that are applicable to both males and females.
Eligibility
Inclusion Criteria4
- Healthy males and females aged 20-30 years
- Females with a regular menstrual cycle
- Stable body weight, defined as no significant change in body weight during the past 6 months
- Willingness to participate and provide written informed consent
Exclusion Criteria10
- Obesity, defined as:
- Body mass index (BMI) \> 30 kg/m²
- Body fat percentage \> 25% in males
- Body fat percentage \> 30% in females
- Hypertension, defined as resting blood pressure \> 140/90 mmHg
- History of cardiovascular disease
- History of cancer
- History of liver disease
- History of kidney disease
- Presence of any medical condition that may interfere with study outcomes
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Interventions
Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 120 sec of rest between sets.
During the early follicular phase, participants completed a standardized resistance exercise protocol consisting of squat, bench press, and deadlift, performed in a fixed order. Each exercise comprised three sets of seven repetitions at 70% of one-repetition maximum (1RM), with 120 s of rest between sets.
Locations(1)
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NCT07444021