Effect of a High-Protein, High-Fiber Pre-Fast Meal on Satiety and Glycemic Profiles During Fasting
Effect of a High-Protein, High-Fiber Pre-Fast Meal on Satiety and Glycemic Profiles During Fasting: A Randomized Crossover Study
King Faisal University
38 participants
Feb 23, 2026
INTERVENTIONAL
Conditions
Summary
This randomized crossover study investigates the effect of consuming a high-protein, high-fiber pre-fast meal on subjective satiety and glycemic responses during fasting hours in healthy adults. Participants will complete two dietary conditions in a randomized order: a standardized high-protein, high-fiber pre-fast meal and a low-protein, low-fiber pre-fast meal guided by dietary instructions. Each condition will be followed for two consecutive days and separated by a three-day washout period. Outcomes include subjective appetite sensations during fasting hours, glycemic profiles assessed using continuous glucose monitoring (CGM), and exploratory analyses examining the association between glucose dynamics and appetite sensations.
Eligibility
Inclusion Criteria3
- Adults aged 18 years and older
- Willingness to comply with study procedures, including fasting and continuous glucose monitoring
- Ability to provide informed consent
Exclusion Criteria5
- Diagnosed diabetes mellitus or known metabolic disease
- History of cardiovascular, gastrointestinal, or endocrine disorders that may affect study outcomes
- Use of medications known to affect glucose metabolism or appetite
- Pregnancy or lactation
- Known allergy or intolerance to any study meal components (oats, dairy, peanuts, nuts, cranberries)
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Interventions
Participants consume a standardized high-protein, high-fiber pre-fast meal consisting of oats (40 g), Greek yogurt (160 g), peanut butter (16 g), dried cranberries (10 g), and almonds (6 g) for two consecutive days.
Participants follow standardized written dietary instructions, including a list of foods to avoid, to consume a low-protein, low-fiber pre-fast meal for two consecutive days. No calorie restriction is applied.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07447505