Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases
Masaryk University
70 participants
Mar 1, 2026
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.
Eligibility
Inclusion Criteria1
- Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI).
Exclusion Criteria5
- Any severe psychiatric disorder.
- History of other neurological diseases affecting the central nervous system.
- Severe head trauma.
- Uncompensated internal or oncological disease.
- Presence of MRI-incompatible metal in the body (e.g., pacemaker).
Interventions
Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.
Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.
Locations(1)
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NCT07449117