RecruitingNot ApplicableNCT07449117

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases


Sponsor

Masaryk University

Enrollment

70 participants

Start Date

Mar 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.


Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new non-invasive brain stimulation technique called temporal interference stimulation — which uses painless electrical signals to target deep brain areas — to see if it can improve language and communication abilities in people with early-stage memory and thinking problems related to neurodegenerative diseases like Parkinson's disease and Lewy body dementia. **You may be eligible if:** - You have been diagnosed with mild cognitive impairment (MCI) associated with Lewy bodies, Parkinson's disease, or amnestic MCI (a type of early memory decline) - You have been evaluated and meet established diagnostic criteria for one of these conditions **You may NOT be eligible if:** - You have a severe psychiatric disorder - You have another neurological condition affecting the central nervous system (beyond the ones listed above) - You have had severe head trauma - You have uncontrolled serious medical or cancer-related illness - You have metal implants in your body that are incompatible with the stimulation device (e.g., a pacemaker) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive Temporal Interference Stimulation (TIS)

Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.

DEVICEPlacebo / Sham TIS

Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.


Locations(1)

CEITEC MU (Central European Institute of Technology, Masaryk University)

Brno, South Moravian, Czechia

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NCT07449117


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