RecruitingNCT07452848

Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy

Impact of Pringle Maneuver on the Occurrence of Postoperative Gallbladder Diseases After Hepatectomy: A Multicenter Retrospective Cohort Study


Sponsor

West China Hospital

Enrollment

2,000 participants

Start Date

Mar 1, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

The liver is an organ with a rich blood supply. During liver surgery (hepatectomy), surgeons often temporarily clamp the blood vessels supplying the liver to maintain a clear surgical field and reduce bleeding. This common technique is known as the Pringle maneuver. However, this maneuver also temporarily cuts off the blood supply to the gallbladder. Currently, doctors debate whether to routinely remove a healthy gallbladder during liver surgery to prevent future gallbladder problems, or to preserve it. The primary purpose of this multicenter retrospective cohort study is to evaluate whether using the Pringle maneuver during liver surgery increases the risk of patients developing gallbladder diseases (such as gallstones or inflammation) later on. Researchers will review the past medical records of patients who underwent liver surgery with their gallbladder preserved between January 2012 and January 2022. By comparing patients who had the Pringle maneuver with those who did not, the study aims to provide reliable clinical evidence to help surgeons make better decisions about whether to preserve or remove the gallbladder during liver surgery.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria5

  • Aged 18 to 85 years.
  • Definitive diagnosis of hepatic solid lesions confirmed by imaging (such as CT, MRI, or ultrasound) and/or pathology.
  • Underwent elective hepatectomy with gallbladder preservation.
  • Preoperative liver function evaluated as Child-Pugh class A or B.
  • Preoperative American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.

Exclusion Criteria5

  • Preoperative evaluation indicating pre-existing biliary tract diseases (e.g., cholelithiasis, biliary inflammation, neoplastic lesions).
  • History of previous upper abdominal surgery.
  • Application of non-hepatic inflow occlusion methods during surgery (e.g., hemihepatic vascular occlusion, selective segmental vascular occlusion).
  • Personal history of long-term use of hormone replacement therapy, somatostatin and its analogues, or oral contraceptives.
  • Loss to follow-up or missing critical data postoperatively.

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Interventions

PROCEDUREPringle maneuver

A surgical technique utilized during hepatectomy that involves the temporary clamping of the hepatic hilum to control and reduce intraoperative blood loss.


Locations(8)

The First Affiliated Hospital of University of Science and Technology of China

Hefei, Anhui, China

Xinqiao Hospital of Army Medical Universit

Chongqing, Chongqing Municipality, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China

Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, China

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NCT07452848


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