RecruitingNCT07456202

Menstrual Status, Anesthetic Consumption, and PONV

Impact of Menstrual Phases and Menopause on Intraoperative Anesthetic Consumption and Postoperative Nausea and Vomiting: A Prospective Observational Study

Sponsor

Ankara Etlik City Hospital

Enrollment

120 participants

Start Date

Mar 7, 2026

Study Type

OBSERVATIONAL

Conditions

Menstrual Cycle

Summary

This prospective observational cohort study aims to evaluate the association between menstrual phase (determined by postoperative serum progesterone levels), intraoperative anesthetic consumption, and the incidence and severity of postoperative nausea and vomiting (PONV) in female patients undergoing cholecystectomy. Intraoperative anesthetic requirements will be recorded, and postoperative nausea and vomiting will be assessed using standardized scoring systems.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

Female patients aged 18 to 65 years
American Society of Anesthesiologists (ASA) physical status I-II-III
Scheduled for elective laparoscopic cholecystectomy under general anesthesia
Willing and able to provide written informed consent

Exclusion Criteria16

Age outside the specified range (younger than 18 or older than 65 years)
Male patients
American Society of Anesthesiologists (ASA) physical status ≥ IV
Severe systemic comorbidities (e.g., significant cardiovascular, hepatic, renal, or pulmonary disease)
Conversion from laparoscopic to open cholecystectomy
History of alcohol, drug, or substance abuse
Visual or hearing impairment interfering with study assessments
Current hormone replacement therapy
Use of oral contraceptives
Preoperative nausea or vomiting
History of severe postoperative nausea and vomiting
Neurological or psychiatric disorders affecting assessment reliability
Hemodynamic instability during surgery
Postoperative admission to intensive care unit
Acute cholecystitis at the time of surgery
Refusal to participate or inability to provide informed consent