RecruitingEarly Phase 1NCT07457736

Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1

Sponsor

Yale University

Enrollment

32 participants

Start Date

Apr 1, 2026

Study Type

INTERVENTIONAL

Conditions

healthy adult participants

Summary

Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria5

Willing and able to give voluntary written informed consent;
Able to read and write, able to communicate effectively with the investigator, and comply with all study requirements, restrictions, and directions of the research staff;
Male or female, aged 18 to 60, at screening;
In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry, hematology, and serology tests;
Females of childbearing potential, and male subjects, must be willing to practice birth control for the duration of the study (unless medical documentation is provided confirming subject is permanently sterile).