RecruitingNot ApplicableNCT07462000

Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract

Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients

Sponsor

Military Institute od Medicine National Research Institute

Enrollment

40 participants

Start Date

Jan 21, 2026

Study Type

INTERVENTIONAL

Conditions

Cataract Primary Open Angle Glaucoma (POAG)

Summary

This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting and analyzing fluid and tissue samples from eyes during cataract surgery to better understand glaucoma — a condition that damages the optic nerve and can lead to vision loss. Researchers hope to discover new biological markers that explain why glaucoma develops. **You may be eligible if...** - You are 18 years or older - You are scheduled for cataract surgery - For the glaucoma group: you have open-angle glaucoma and are having combined cataract and glaucoma surgery - For the control group: you have cataracts but no glaucoma - You can provide written consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have a different type of glaucoma (such as angle-closure or secondary glaucoma) - You have had previous eye surgery - Your vision in the study eye is very limited - You are under 18 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREPhacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy

Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.

PROCEDUREPhacoemulsification With Intraocular Lens Implantation

Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.