Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients
Military Institute od Medicine National Research Institute
40 participants
Jan 21, 2026
INTERVENTIONAL
Conditions
Summary
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Eligibility
Inclusion Criteria5
- Age ≥ 18 years.
- Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).
- Ability to provide written informed consent.
- For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.
- For control arm: cataract without glaucoma and without other significant ocular pathology.
Exclusion Criteria8
- Age \< 18 years.
- Pregnancy or breastfeeding.
- Advanced visual impairment in the study eye (visual aquity worse than counting fingers).
- Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).
- History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery.
- Active or previous uveitis.
- Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm).
- Inability to comply with study procedures or follow-up visits.
Interventions
Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.
Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.
Locations(2)
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NCT07462000