RecruitingPhase 2NCT07463183

A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-8690 in Adult Participants With Moderately to Severely Active Ulcerative Colitis

Sponsor

Merck Sharp & Dohme LLC

Enrollment

100 participants

Start Date

Mar 24, 2026

Study Type

INTERVENTIONAL

Conditions

Ulcerative Colitis Colitis Ulcerative

Summary

The purpose of this protocol is to evaluate the efficacy of MK-8690 in participants with moderately to severely active ulcerative colitis. The primary hypothesis is that MK-8690 is superior to placebo with respect to the proportion of participants achieving clinical remission per Modified Mayo Score at Week 12.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called MK-8690 and Placebo for people with colitis ulcerative and ulcerative colitis. The study is currently recruiting participants at 8 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMK-8690

Solution for subcutaneous injection

OTHERPlacebo

Solution for subcutaneous injection

Locations(35)

Clinnova Research ( Site 1042)

Anaheim, California, United States

Southern California Research Center ( Site 1044)

Coronado, California, United States

Peak Gastroenterology Associates ( Site 1052)

Colorado Springs, Colorado, United States

South Denver Gastroenterology, PC ( Site 1068)

Englewood, Colorado, United States

Nature Coast Clinical Research ( Site 1045)

Inverness, Florida, United States

Research Associates of South Florida - Miami - Southwest 8th Street ( Site 1072)

Miami, Florida, United States

AdventHealth Orlando ( Site 1074)

Orlando, Florida, United States

Gastroenterology Associates of Central Georgia ( Site 1060)

Macon, Georgia, United States

University of Kansas Medical Center ( Site 1077)

Kansas City, Kansas, United States

Tulane University School of Medicine-Gastroenterology and Hepatology ( Site 1073)

New Orleans, Louisiana, United States

BVL Research - Kansas ( Site 1054)

Liberty, Missouri, United States

Prairie Institute of Liver and Luminal Advanced Research ( Site 1008)

Lethbridge, Alberta, Canada

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 1001)

Montreal, Quebec, Canada

Servicios de Salud IPS Suramericana S.A.S. - IPS Sura Industriales Medellín ( Site 1163)

Medellín, Antioquia, Colombia

Clinica de la Costa S.A.S. ( Site 1161)

Barranquilla, Atlántico, Colombia

Fundacion Santa Fe de Bogota ( Site 1165)

Bogota, Cundinamarca, Colombia

Fundación Valle del Lili ( Site 1162)

Cali, Valle del Cauca Department, Colombia

Centre Hospitalier Dr Schaffner ( Site 1288)

Lens, Pas-de-Calais, France

Clinique Jules Verne ( Site 1284)

Nantes, Pays de la Loire Region, France

Universitaetsklinikum Ulm. ( Site 1324)

Ulm, Baden-Wurttemberg, Germany

Evangelismos General Hospital of Athens ( Site 1362)

Athens, Attica, Greece

THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 1361)

Athens, Attica, Greece

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1404)

Bologna, Emilia-Romagna, Italy

Radboudumc ( Site 1650)

Nijmegen, Gelderland, Netherlands

Amsterdam UMC, locatie VUmc ( Site 1651)

Amsterdam, North Holland, Netherlands

PROMED P. LACH R. GLOWACKI SP. J. ( Site 1447)

Krakow, Lesser Poland Voivodeship, Poland

Melita Medical Sp Zoo ( Site 1442)

Wroclaw, Lower Silesian Voivodeship, Poland

EB Group Sp. Z o.o. Centrum Zdrowia MDM ( Site 1449)

Warsaw, Masovian Voivodeship, Poland

Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś ( Site 1448)

Warsaw, Masovian Voivodeship, Poland

Twoja Przychodnia - Szczeciskie Centrum Medyczne ( Site 1450)

Szczecin, West Pomeranian Voivodeship, Poland

Wonju Severance Christian Hospital ( Site 1602)

Wŏnju, Kang-won-do, South Korea

Korea University Ansan Hospital ( Site 1603)

Ansan-si, Kyonggi-do, South Korea

Kangbuk Samsung Hospital ( Site 1601)

Seoul, South Korea

Fairfield General Hospital ( Site 1524)

Bury, Lancashire, United Kingdom

Huddersfield Royal Infirmary ( Site 1522)

Huddersfield, York, United Kingdom

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NCT07463183

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