RecruitingPhase 1NCT07466550

A Study to Assess How Intravenous and Subcutaneous Administrations of Risankizumab Moves Through the Body of Healthy Adult Participants

A Phase 1 Study in Healthy Subjects to Assess Pharmacokinetics Following Intravenous and Subcutaneous Administration of Risankizumab

Sponsor

AbbVie

Enrollment

60 participants

Start Date

Jun 4, 2026

Study Type

INTERVENTIONAL

Conditions

Healthy Volunteer

Summary

The purpose of this study is to compare how the drug moves through the body following risankizumab subcutaneous (SC) and risankizumab intravenous (IV) doses.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

Body weight between 40 kg and 100 kg inclusive at screening and upon initial confinement.
BMI is ≥ 18.0 to ≤ 32.0 kg/m2 after rounding to the tenths decimal at Screening. BMI is calculated as weight in kg divided by the square of height measured in meters.
A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead ECG.

Exclusion Criteria2

Exposure to any anti-interleukin-12/23 or anti interleukin-23 treatment for at least one year prior to Screening.
Intention to perform strenuous exercise to which the subject is unaccustomed within one week prior to administration of first dose of study treatment or during the study.

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