Serum Inflammatory Protein Concentration During Dental Treatment
Systemic Molecular Markers of Surgical Trauma in Periodontitis/Peri-implantitis Patients
Ohio State University
30 participants
Jul 13, 2026
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are: * How do the levels of inflammatory molecules in the blood change during a periodontal surgery? * How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure? * Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.
Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs
Regular cleaning to maintain health after surgical treatment for periodontal disease
Debridement under local anesthesia, as based on treatment needs
Locations(1)
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NCT07468929