Periodontal Disease Clinical Trials

74 recruitingLast updated: June 18, 2026

There are 74 actively recruiting periodontal disease clinical trials across 31 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Izmir, Çiğli, Turkey (Türkiye), Pavia, Lombardy, Italy, London, United Kingdom. Updated daily from ClinicalTrials.gov.


Periodontal Disease Trials at a Glance

74 actively recruiting trials for periodontal disease are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 47 trials, with the heaviest enrollment activity in Izmir, Pavia, and London. Lead sponsors running periodontal disease studies include G. d'Annunzio University, Izmir Katip Celebi University, and Universidad de Murcia.

Browse periodontal disease trials by phase

Treatments under study

About Periodontal Disease Clinical Trials

Looking for clinical trials for Periodontal Disease? There are currently 21 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Periodontal Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Periodontal Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 74 trials

Recruiting
Not Applicable

The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases

GingivitisPeriodontal DiseasesVitamin D Deficiency
Recep Tayyip Erdogan University Training and Research Hospital120 enrolled1 locationNCT07636733
Recruiting

Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

Healthy VolunteerImmunosuppressionPeriodontal Disease+1 more
National Institute of Dental and Craniofacial Research (NIDCR)700 enrolled1 locationNCT01568697
Recruiting
Not Applicable

Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects

Periodontal DiseasesPeriodontal Attachment LossPocket, Periodontal+1 more
G. d'Annunzio University88 enrolled1 locationNCT05858411
Recruiting

Oral Health and Systemic Diseases: Survey of General Practitioners

Periodontal DiseaseDiabete Mellitus
University of Roma La Sapienza100 enrolled1 locationNCT07604493
Recruiting
Not Applicable

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

Gum diseasePeriodontal DiseasesPeriodontitis
Erchonia Corporation70 enrolled2 locationsNCT06656325
Recruiting
Not Applicable

Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During Orthodontic Treatment: A Split-Mouth Study.

Periodontal DiseasesOral HealthMalocclusion
George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures39 enrolled1 locationNCT07533058
Recruiting

Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax

PeriodontitisGingivitis and Periodontal Diseases
Abant Izzet Baysal University120 enrolled1 locationNCT07551115
Recruiting
Not Applicable

Comparison Between Different Interdental Brushes in Adults With Periodontal Disease.

Periodontal Disease
Pierre Fabre Dermo Cosmetique88 enrolled1 locationNCT07575997
Recruiting

Candida Albicans in Syrian Patients With Periodontitis

Periodontal DiseasesPeriodontitisPeriodontal Disease
Al-Hawash Private University100 enrolled1 locationNCT07574827
Recruiting

Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population Using Semi-Supervised Learning

GingivitisPeriodontal DiseasesPeriodontitis
Universiti Sains Malaysia393 enrolled1 locationNCT07410351
Recruiting
Phase 4

Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies

AntibioticsPeriodontal DiseasesPharmacokinetics
University of Geneva, Switzerland45 enrolled1 locationNCT04669717
Recruiting

ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE

GingivitisPeriodontal DiseasesPeriodontitis
Abant Izzet Baysal University160 enrolled1 locationNCT07530978
Recruiting

Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)

GingivitisPeriodontitisPeriodontal Disease
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University2,000 enrolled3 locationsNCT07406867
Recruiting

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

periodontal inflammationPeriodontal DiseasesPeriodontitis+2 more
University of Chile30 enrolled1 locationNCT07536204
Recruiting
Not Applicable

PMPR and Chlorhexidine on Periodontal Disease and Vascular Function

Vascular DysfunctionCardio Vascular DiseasePeriodontal Disease (PD)+2 more
Mahdi Mutahar30 enrolled1 locationNCT07311512
Recruiting
Not Applicable

NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery

GingivitisPeriodontal DiseasesGingival Diseases
Aesculap AG84 enrolled1 locationNCT05813236
Recruiting
Not Applicable

Evaluation of Toothbrush Bristles

Gingivitis and Periodontal Diseases
State University of New York at Buffalo70 enrolled1 locationNCT07306026
Recruiting
Not Applicable

Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy

Periodontal DiseasePeriodontal Attachment LossPeriodontal Pockets
Tel Aviv University20 enrolled1 locationNCT07446127
Recruiting
Not Applicable

Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy

PregnancyMicrobiotaGingivitis+4 more
University of Pavia40 enrolled1 locationNCT07029360
Recruiting
Not Applicable

Lactoferrin-Based Oral Care for Periodontal Health in Pregnancy

PregnancyGingivitisOral Microbiota+1 more
University of Pavia40 enrolled1 locationNCT07069140