RecruitingNot ApplicableNCT07469540

Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis


Sponsor

Jérôme Bouchan

Enrollment

90 participants

Start Date

Mar 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease. The main questions this study aims to address are: * Does an individualized aerobic exercise program reduce cardiovascular risk, as assessed arterial stiffness and endothelial function ? * What are the effects of this exercise program on inflammation and immunosenescence? Researchers will compare an individualized aerobic exercise program with a therapeutic education program (consisting of educational phone calls only) and a control group with no intervention. Participants will: * Perform three physical activity sessions per week for six weeks (45-minute sessions at 60-80% of heart rate reserve); * Attend clinic visits at baseline, after the 6-week intervention, and at a 6-week follow-up after the intervention; * Undergo assessments including pulse wave velocity, hyperemic reactivity, and blood analyses.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a structured aerobic exercise program can reduce cardiovascular (heart and blood vessel) risk in people living with chronic kidney disease (CKD) or rheumatoid arthritis (RA) — two conditions that significantly raise the risk of heart problems. **You may be eligible if...** - You have been diagnosed with chronic kidney disease (stage 3 or 4, not on dialysis) or rheumatoid arthritis with active disease - You have a medical certificate confirming you can safely do physical exercise - You are enrolled in a French social security health scheme **You may NOT be eligible if...** - You are on unstabilized steroid therapy or taking more than 10 mg of prednisone per day - You have uncontrolled high blood pressure - You are pregnant - You have a condition (neurological, cardiovascular, respiratory, or musculoskeletal) that prevents you from exercising - You are unable to understand or follow an exercise program - You do not have health insurance - You are currently enrolled in another study that could affect your heart or inflammation levels Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAerobic exercise program

Aerobic exercise program during 6 weeks, with 3 sessions / week. Each session includes 45 minutes of ergocycle, with 9 cycles of 4 minutes at 60% of heart rate and 1 minute at 80%.

BEHAVIORALTherapeutic education

Therapeutic education for 6 weeks, with one telephone call per week. Each call includes advices and exchanges to improve physical activity level.


Locations(1)

EPHI Platform

Besançon, France

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NCT07469540


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