RecruitingNCT04014348

Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

Pilot Study for Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women


Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Enrollment

250 participants

Start Date

Oct 20, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

Background: Heart disease is a leading cause of death in the United States. Healthy diet and exercise improve heart health. Some features of where a person lives can lead to stress and decrease chances for exercise. Researchers want to see how these factors may increase the risk of heart disease in women. Objective: To see if there are differences in stress levels between women who live in different parts of Washington, DC. Also, to see how these women use their neighborhoods for exercise. Eligibility: Healthy white or black females ages 19-45 who live in Washington, DC, who have access to a smartphone Design: Participants may stay at the NIH Clinical Center overnight for a 2-day visit. Visit 1 will include: Physical exam Blood tests Electrocardiogram: Electrodes on the participant s skin will measure heart activity. PET/CT scan: Participants will get an injection. They will lie in a machine that takes pictures of the body. Surveys Body size measurements Nutrition consultation Blood vessel tests: This is measured with blood pressure cuffs, a device placed on the participant s fingertip, and a probe placed on the participant s neck. Resting Energy Expenditure: Participants will breathe under a clear hood for 45 minutes. Participants will be followed for about 2 weeks. They will wear a device on the wrist and carry a GPS device. Through a mobile app, they will answer short daily surveys on stress and exercise. Visit 2- Device return Nutritional consultation


Eligibility

Sex: FEMALEMin Age: 19 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study examines how the neighborhood environment — including factors like poverty, crime, noise, and pollution — affects the heart health and behaviors of women living in Washington, D.C. It focuses specifically on White and Black women, as Black women in the U.S. face disproportionately higher rates of cardiovascular disease. Researchers want to understand whether neighborhood stress contributes to this disparity through biological and behavioral pathways. Environmental stress is not just psychological — it can alter hormones, inflammation, blood pressure, and metabolism in ways that raise heart disease risk. By combining detailed neighborhood data (using geospatial mapping) with blood and behavioral measurements, this study aims to show exactly how the places where we live can affect our physical health. **You may be eligible if...** - You are a woman who self-identifies as White (or of European descent) or Black (African American, or of African descent) - You are between 19 and 45 years of age - You do not have any chronic health conditions (cardiovascular, autoimmune, or endocrinological) - You do not have an active infection - You live in Washington, D.C. - You have access to a smartphone and speak English **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are physically unable to exercise - Your weight has changed by more than 20% in the past 3 months - Your BMI is 35 or higher - You have high or low blood pressure requiring medication - You have diabetes, thyroid disease, or severe mental illness requiring hospitalization - You currently smoke - You have food allergies or restrictions that prevent eating a controlled diet **Talk to your doctor** about your current health status, medications, and whether you are free of chronic conditions that would affect this study.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

National Institutes of Health Clinical Center

Bethesda, Maryland, United States

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NCT04014348


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