An Analysis of Healthy Caucasian Knees
An Analysis of Healthy Caucasian Knees: Variability in Threedimensional Anatomy, Mediolateral Ligamentous Balance, Lower Limb Alignment and Trabecular Micro-structure.
Universitaire Ziekenhuizen KU Leuven
200 participants
Aug 8, 2025
INTERVENTIONAL
Conditions
Summary
In current literature, databases of healthy knee anatomy and function are confined to small sample sizes or singular imaging modalities. In this study, the investigator propose constructing a unique and large-scale database of healthy Caucasian knee anatomy and function by utilizing a combination of ultra-high resolution capabilities from photon-counting CT, lower limb weightbearing orthogonal imaging (EOS) of full leg, and non-invasive ultrasound-based functional testing of the knee. This study is a collaborative effort between the orthopaedics, radiology and biomechanical engineering departments in which the same prospectively acquired database will be used for multiple independent research questions.
Eligibility
Inclusion Criteria9
- Aged 20-35 years old.
- 'Caucasian':
- Self-identification as Caucasian or of European descent.
- Self-identification as having 'fair' skin tone.
- Both parents and all grandparents are of Caucasian or European descent.
- Healthy knee and lower limb:
- No bony orthopaedic or trauma history in the lower limb (pelvis - foot).
- No ligamentary or soft tissue trauma history in the knee.
- No ligamentary or soft tissue trauma in the lower limb requiring cast immobilization.
Exclusion Criteria4
- Individuals identifying with a race or ethnicity other than Caucasian or European descent.
- Participants with known mixed racial or ethnic backgrounds that include non-Caucasian ancestry.
- Participant uncertainty of pregnancy status.
- Open wounds over the knee joint.
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Interventions
CT scan images of the knee allow for detailed anatomical analysis of joint shape through the means of statistical shape modelling.
Software-based reconstruction of orthogonal images provided by EOS imaging allows for a comprehensive three-dimensional analysis of lower limb alignment without the need for a full leg CT scan, minimizing exposure to ionizing radiation in the pelvic region.
For the analysis of constitutional balance, this study will use an ultrasound-based technique. This is a non-invasive and previously validated method of determining medio-lateral laxity of the knee joint.
Locations(1)
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NCT07470671