RecruitingNCT07472686

Small Bowel Capsule Endoscopy in Lynch Syndrome

Small Bowel Capsule Endoscopy for (Pre)Neoplastic Lesion Screening in Patients With Lynch Syndrome

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

400 participants

Start Date

Jun 16, 2025

Study Type

OBSERVATIONAL

Conditions

Cancer Lynch Syndrome MMR Mutation Small Bowel Adenoma Small-bowel Adenocarcinoma

Summary

The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown. The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a small camera capsule swallowed like a pill (capsule endoscopy) can detect early or pre-cancerous growths in the small intestine of people with Lynch syndrome — a hereditary condition that increases the risk of several cancers. **You may be eligible if...** - You carry a known harmful change (mutation) in one of the DNA repair genes linked to Lynch syndrome (MLH1, MSH2, MSH6, PMS2, or EPCAM) - You are scheduled for small bowel screening - You are willing to allow your health data to be used for research **You may NOT be eligible if...** - You do not have a documented Lynch syndrome gene mutation - You object to your data being used in the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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