Small Bowel Capsule Endoscopy in Lynch Syndrome
Small Bowel Capsule Endoscopy for (Pre)Neoplastic Lesion Screening in Patients With Lynch Syndrome
Assistance Publique - Hôpitaux de Paris
400 participants
Jun 16, 2025
OBSERVATIONAL
Conditions
Summary
The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown. The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.
Eligibility
Inclusion Criteria3
- Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)
- Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine
- No opposition to the reuse of healthcare data for research purposes
Exclusion Criteria2
- Absence of documented MMR gene variant
- Opposition to the study
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07472686