RecruitingPhase 1Phase 2NCT07477912

Anti BCMA CAR- T Cell Therapy for Adults With Relapsed or Refractory Multiple Myeloma

Phase I/II Open-label Study Evaluating The Safety And Efficacy of Anti BCMA CAR-T Cell Therapy in Adults With R/ R Multiple Myeloma


Sponsor

Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology

Enrollment

30 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The mail purpose of this study is to estimate the safety and the efficacy of anti-BCMA CAR- T cell immunotherapy for adults with relapsed or refractory multiple myeloma


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a CAR-T cell therapy — where a patient's own immune cells are re-engineered to target and kill cancer cells — for people with multiple myeloma (a blood cancer) that has come back or stopped responding to treatment. The therapy targets a protein on myeloma cells called BCMA. **You may be eligible if...** - You are 18 or older - You have multiple myeloma that has returned or is no longer responding to treatment - You have already received at least 2 prior treatment regimens, including drugs that target the proteasome and immune-modulating drugs - Your heart, kidneys, liver, and blood counts meet required levels - Your overall health is reasonably good (ECOG 0–2) **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have had a stroke within the past 3 months, severe brain injury, dementia, or uncontrolled psychiatric illness - Cancer has spread to your brain or spinal cord - You have active graft-versus-host disease (from a prior bone marrow transplant) - Your blood counts or organ function are too low Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BIOLOGICALanti BCMA CAR-T cells

Following preconditioning with chemotherapy (cyclophosphamide and fludarabine) patients will be treated with doses from 50 x 10⁶ to 250 x 10⁶ anti BCMA CAR-T cells


Locations(1)

State Institution Minsk Scientific and Practical Center for Surgery, Transplantology, and Hematology

Minsk, Belarus

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07477912


Related Trials