RecruitingNot ApplicableNCT07478185

Prehab for Pancreatic Cancer Surgery

Multimodal Prehabilitation Prior to Pancreatic Cancer Surgery: A Pilot Study


Sponsor

University of Massachusetts, Worcester

Enrollment

20 participants

Start Date

Mar 31, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical study is to test whether a structured prehabilitation program can be successfully used by adults with pancreatic cancer who are receiving chemotherapy before planned surgery. Prehabilitation is a program designed to improve a person's physical fitness, nutrition, and symptom control before surgery. The study's main hypothesis is that patients with pancreatic cancer can take part in and adhere to a multimodal prehabilitation program during chemotherapy, and that doing so may improve physical function, patient experience, and early recovery after surgery.


Eligibility

Min Age: 18 Years

Inclusion Criteria6

  • Age ≥ 18 years
  • Diagnosis of pancreatic ductal adenocarcinoma (PDAC)
  • Planned neoadjuvant chemotherapy prior to planned surgical resection
  • Medically stable and cleared to participate in physical activity/exercise programming
  • Able to provide informed consent
  • Ability to read, write and understand English

Exclusion Criteria5

  • Age \<18 years
  • Pregnant
  • Prisoner
  • Severe cognitive impairment that precludes informed consent or participation
  • Contraindications to physical activity, including unstable cardiac disease, severe pulmonary disease, or recent myocardial infarction

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Interventions

BEHAVIORALMultimodal Prehabilitation

Participants will receive a structured, multimodal prehabilitation program delivered during neoadjuvant chemotherapy prior to planned pancreatic cancer surgery. The program integrates supervised, individualized exercise training, nutritional assessment and counseling with recommended preoperative immunonutrition, and supportive care focused on symptom management and functional support. Prehabilitation is delivered as an integrated component of preoperative care and continues through completion of neoadjuvant therapy until surgery.


Locations(1)

UMass Memorial Medical Center

Worester, Massachusetts, United States

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NCT07478185


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