RecruitingNot ApplicableNCT07479095

Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma


Sponsor

Fondazione del Piemonte per l'Oncologia

Enrollment

30 participants

Start Date

Jul 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether following a low-sugar, high-fat (ketogenic-style) diet for 7 days before a PET/CT scan can improve the accuracy of detecting a slow-growing type of lung cancer called lepidic-predominant adenocarcinoma (LPA). Standard PET scans sometimes miss this cancer because it doesn't use as much sugar as other tumors. **You may be eligible if...** - You are 18 or older - A CT scan has found a lung nodule that may be this type of cancer, or a biopsy has confirmed it - The nodule is at least 10mm in size - Your general health is good enough to participate (ECOG 0–2) - You are willing and able to follow a controlled ketogenic diet for 7 days **You may NOT be eligible if...** - You have kidney failure - You have type 1 diabetes - You have pancreatitis or severe cholesterol problems - You have had another active cancer in the past 3 years - You have serious psychiatric or medical conditions that would prevent participation - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALKetogenic diet

Tailored low-glucose/high-fat ketogenic dietary regimen administered for 7 consecutive days before 2-\[18F\]FDG PET/CT. Compliance will be assessed by clinical review, laboratory testing, and urinalysis on the day of PET/CT.

DIAGNOSTIC_TEST2-[18F]FDG PET/CT

FDG PET/CT performed after completion of the 7-day ketogenic diet. Images will undergo visual and semiquantitative assessment, including comparison of target nodule uptake with mediastinal blood pool background and measurement of SUVmax.


Locations(1)

Fondazione del Piemonte per l'Oncologia- IRCCS Istituto di Candiolo, Candiolo, Turin 10060

Candiolo, Torino (TO), Italy

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NCT07479095


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