An Open-label Extension Safety and Efficacy Study of QCZ484 in Hypertensive Patients.

Exclusion Criteria6

• Participants meeting any of the following criteria, may it be pre-existing or developed during the parent study, are not eligible for inclusion in this study:
• Evidence of hepatic disease that would put participant at risk by taking QCZ484 for long term as determined by the Investigator.
• Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia), high-grade atrioventricular (AV) block (e.g., Mobitz type II and third-degree AV block in absence of a pacemaker) developed during the parent study.
• Permanent or persistent atrial fibrillation developed during the parent study.
• Clinically significant valvular heart disease developed during the parent study.
• Acute myocardial infarction (AMI) or unstable angina, or any percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) developed during the parent study. Any history of ischemic or hemorrhagic stroke or transient ischemic attack any time prior to enrollment.