RecruitingNot ApplicableNCT07480785

TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk Patients

Transcutaneous Electrical Acupoint Stimulation Combined With Triple Antiemetic Drugs for Postoperative Nausea and Vomiting in High-Risk Patients: A Multicenter Randomized Controlled Trial


Sponsor

Zhejiang University

Enrollment

780 participants

Start Date

Jan 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) combined with triple antiemetics for postoperative nausea and vomiting (PONV) in high-risk patients. The primary question it seeks to answer is: Does TEAS combined with triple antiemetics further reduce the incidence of PONV in high-risk subjects? Researchers will compare active TEAS with sham stimulation to determine whether the addition of TEAS to dexamethasone, palonosetron, and droperidol lowers the PONV rate beyond that achieved by the triple-drug prophylaxis alone.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining acupuncture-like electrical stimulation on the wrist (called TEAS) with three anti-nausea medications can better prevent nausea and vomiting after surgery in women who are at high risk for this side effect. Post-surgery nausea and vomiting is a common problem that can make recovery very uncomfortable. **You may be eligible if...** - You are a woman aged 18–65 scheduled for laparoscopic (keyhole) surgery - You are in generally good enough health to undergo surgery (ASA class I–III) - You have at least 3 of the following risk factors: female, non-smoker, history of nausea/vomiting after surgery or motion sickness **You may NOT be eligible if...** - You have a drug allergy or other reason you cannot take the study medications - You have a heart condition called long-QT syndrome - You are pregnant, breastfeeding, or currently menstruating - You are a current smoker - You have a serious kidney or liver condition - You have a psychiatric or neurological disorder - You have a skin wound or infection where the wrist stimulation would be placed - You have an implanted pacemaker or defibrillator - You participated in another clinical trial in the past 4 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEtranscutaneous electrical acupoint stimulation

Using the Huatuo brand electronic acupuncture therapy device (Model: SDZ-Ⅲ, produced by Suzhou Medical Equipment Co., Ltd., China), bilateral upper limb acupoints P6+L14 were selected. Approximately 30 minutes before anesthesia induction, the electrodes were connected with the initial current set at 1 milliampere and frequency at 2/100 Hz. The current intensity was gradually increased until the patient felt pain or reached the discomfort threshold (ranging between 6 to 10 mA), and the stimulation was maintained until the patient was discharged from the PACU.

DEVICESham transcutaneous electrical acupoint stimulation

The same protocol was applied for percutaneous acupoint electrical stimulation, initiated before anesthesia induction with the minimum perceptible current (MPC) and terminated after 1 minute.

DRUGtriple antiemetic drugs

Dexamethasone 5mg and palonosetron 0.25mg i.v. will be given after induction, and droperidol 1.25 mg i.v. will be given during the abdominal closure.


Locations(1)

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

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NCT07480785


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