Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)

This trial (SURMOUNT-1) tests whether tirzepatide, a once-weekly injection, helps people who are overweight or obese safely lose weight over time. You may be eligible if... - Your BMI is 30 or higher, OR your BMI is 27 or higher with at least one weight-related health condition (e.g., high blood pressure, sleep apnea, heart disease) - You have tried and failed at least one diet effort to lose weight - You are 18 or older and able to self-inject or receive injections You may NOT be eligible if... - You have type 1 or type 2 diabetes, or lab results showing diabetes - Your weight has changed by more than 5 kg in the last 3 months - You have had or are planning bariatric (weight loss) surgery - You have severe kidney disease (eGFR below 30) - You have a history of pancreatitis, thyroid problems, or chronic stomach emptying issues - You have a serious psychiatric disorder or history of suicide attempt - Your obesity is caused by a hormonal condition like Cushing's syndrome Talk to your doctor to see if this trial is right for you.