RecruitingPhase 4NCT07487831

The Impact of Salt Intake on Sodium in the Skin and Inflammatory Skin Disease


Sponsor

University of California, San Francisco

Enrollment

50 participants

Start Date

Jul 14, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to demonstrate the feasibility of a trial that examines the impact of changes in dietary sodium intake on skin sodium levels, atopic dermatitis, and psoriasis. In addition, it aims to generate preliminary data to begin to answer the following questions: 1. Is there an association between skin sodium concentration and atopic dermatitis and psoriasis severity? 2. Are changes in dietary sodium are associated with changes in skin sodium concentration and atopic dermatitis and psoriasis severity? Researchers will compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake. Participants will: * Follow a low-salt diet for the duration of the 13-week study * Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa * Visit the clinic up to 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Placebo Tablets and a drug called Sodium chloride tablets for people with psoriasis and atopic dermatitis (eczema). The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSodium chloride tablets

During the 5-week long sodium tablet intervention period, participants will receive five 1 g sodium chloride tablets each morning and four 1 g sodium chloride tablets each evening. Each sodium chloride tablet will contain 0.394 g or 17 mmol of sodium

OTHERPlacebo Tablets

During the 5-week long placebo period, participants will receive five placebo tablets each morning and four placebo tablets each evening.


Locations(2)

UCSF Mt Zion Campus

San Francisco, California, United States

San Francisco VA Medical Center

San Francisco, California, United States

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NCT07487831


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