Efficacy of Behavioral Therapy for Chronic Refractory Cough
Efficacy of Behavioral Therapy for Chronic Refractory Cough in Patients With Laryngeal Hyperresponsiveness
Assiut University
30 participants
Mar 10, 2026
INTERVENTIONAL
Summary
Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients' physical, psychological, and social quality of life. Chronic cough remains a diagnostic and therapeutic challenge despite systematic evaluation and treatment of common etiologies such as asthma, gastroesophageal reflux disease
Eligibility
Inclusion Criteria3
- Eligible participants are adults aged ≥18 years i.e. normal chest radiograph.
- participants with chronic cough persisting for more than eight weeks that is refractory to standard medical treatment for common causes of chronic cough, including asthma, gastroesophageal reflux disease .
- Participants are required to exhibit clinical features suggestive of laryngeal hyperresponsiveness, such as cough triggered by phonation, laughter, cold air, or irritant exposure, with associated laryngeal symptoms including throat irritation, dysphonia, or frequent throat clearing.
Exclusion Criteria4
- Patients are excluded if they are current smokers or had ceased smoking within six months
- patients have evidence of active pulmonary or cardiac disease, recent respiratory tract infection, recent angiotensin-converting enzyme inhibitor use.
- significant structural laryngeal pathology, neurological disorders affecting cough reflex control, or inability to comply with study procedures.
- Head \&neck pathology e.g sinusitis, glottal insufficiency or primary muscle tension dysphonia
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Interventions
to evaluate the efficacy of behavioral therapy for chronic cough in patients with laryngeal hyperresponsiveness in order to assess its role as a non-pharmacological management strategy. This will provide an efficient plan of therapy for such challenging condition.
Locations(1)
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NCT07488598