RecruitingEarly Phase 1NCT07490041

Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases

Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Relapsed/Refractory Pediatric Rheumatic Diseases

Sponsor

The Children's Hospital of Zhejiang University School of Medicine

Enrollment

36 participants

Start Date

Mar 19, 2026

Study Type

INTERVENTIONAL

Conditions

Systemic Lupus Erythematosus (SLE)Rheumatic Diseases Pediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)Connective Tissue Disease-associated Interstitial Lung Disease

Summary

A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA CAR-NK cell injection in patients with refractory pediatric rheumatic diseases.

Eligibility

Min Age: 5 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called KN5601 for people with connective tissue disease-associated interstitial lung disease, pediatric rheumatological condition (i.e., arthritis, sle, kawasaki's disaese), and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 5 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALKN5601

Multiple doses of anti-CD19/BCMA CAR-NK cells (KN5601) will be administered using dose-escalation strategy.

Locations(1)

The Children's Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

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NCT07490041

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