RecruitingPhase 3NCT07496450

A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults

A Phase 3, Randomized, Observer-blind, Placebo-controlled Study to Evaluate the Immunogenicity, Safety, and Reactogenicity of mRNA-1018-H5 Pandemic Influenza Vaccine in Adults ≥18 Years of Age

Sponsor

ModernaTX, Inc.

Enrollment

4,000 participants

Start Date

Mar 23, 2026

Study Type

INTERVENTIONAL

Conditions

Influenza

Summary

The purpose of this study is to evaluate humoral immunogenicity after 2 doses of mRNA-1018-H5, and to evaluate the safety and reactogenicity of mRNA-1018-H5 in adults ≥18 years of age.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Placebo and a biological treatment called mRNA-1018-H5 for people with influenza. The study is currently recruiting participants at 36 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALmRNA-1018-H5

Sterile liquid for injection.

BIOLOGICALPlacebo

Sterile liquid for injection.

Locations(36)

Velocity Clinical Research, San Bernardino

San Bernardino, California, United States

Velocity Clinical Research, Savannah

Savannah, Georgia, United States

Velocity Clinical Research, Boise

Meridian, Idaho, United States

Velocity Clinical Research, Rockville

Rockville, Maryland, United States

Velocity Clinical Research, Omaha

Omaha, Nebraska, United States

Velocity Clinical Research, Cleveland

Beachwood, Ohio, United States

Velocity Clinical Research, Providence

East Greenwich, Rhode Island, United States

Velocity Clinical Research, Anderson

Anderson, South Carolina, United States

Velocity Clinical Research, Dallas

Dallas, Texas, United States

Velocity Clinical Research, Suffolk

Suffolk, Virginia, United States

Velocity Clinical Research-Bristol

Bristol, Bristol (Unitary Authority), United Kingdom

Velocity Clinical Research - High Wycombe

High Wycombe, Buckinghamshire, United Kingdom

Wansford Research Ltd

Peterborough, Cambridgeshire, United Kingdom

Futuremeds Teesside Middlefield Centre University Hospital of North Tees

Stockton-on-Tees, County Durham, United Kingdom

NIHR Wessex CRDC - Bournemouth Research Hub (Under University Hospital Southampton NHS Foundation Trust)

Bournemouth, Dorset, United Kingdom

NIHR Wessex CRDC - Weymouth Research Hub (Under University Hospital Southampton NHS Foundation Trust)

Weymouth, Dorset, United Kingdom

Panthera Glasgow

Glasgow, Glasgow City (Scotland), United Kingdom

Panthera Enfield

Enfield, Greater London, United Kingdom

Hounslow Medical Centre

Hounslow, Greater London, United Kingdom

hVIVO Services Limited

London, Greater London, United Kingdom

Velocity Clinical Research-North London

London, Greater London, United Kingdom

Accellacare North London

Northwood, Greater London, United Kingdom

Accellacare South London

Orpington, Greater London, United Kingdom

Velocity Clinical Research-Romford

Romford, Greater London, United Kingdom

Panthera Rochdale

Rochdale, Greater Manchester, United Kingdom

NIHR Wessex CRDC - Southampton Research Hub (Under University Hospital Southampton NHS FT)

Southampton, Hampshire, United Kingdom

Fylde Coast Clinical Research at Layton Medical Centre

Blackpool, Lancashire, United Kingdom

FutureMeds Liverpool

Metropolitan Borough of Wirral, Merseyside, United Kingdom

Lakeside Healthcare

Corby, North Northamptonshire, United Kingdom

Panthera York

York, North Yorkshire, United Kingdom

The University of Nottingham Health Service

Nottingham, Nottinghamshire, United Kingdom

Panthera Sheffield

Sheffield, South Yorkshire, United Kingdom

FutureMeds Newcastle

Newcastle upon Tyne, Tyne and Wear, United Kingdom

Accellacare Warwickshire

Coventry, West Midlands (Coventry), United Kingdom

FutureMeds Birmingham Soho Road Health Centre

Birmingham, West Midlands, United Kingdom

Accellacare Yorkshire

Shipley, West Yorkshire, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07496450

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