RecruitingPhase 2Phase 3NCT07496567

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)

Sponsor

EyeBiotech Ltd.

Enrollment

960 participants

Start Date

Apr 15, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Aflibercept and a drug called Tiespectus for people with age-related macular degeneration, choroidal neovascularization, and other related conditions. The study is currently recruiting participants at 56 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTiespectus

Administered by intravitreal (IVT) injection

DRUGAflibercept

Administered by intravitreal (IVT) injection

Locations(56)

Associated Retina Consultants - Gilbert

Gilbert, Arizona, United States

The Retina Partners

Encino, California, United States

Northern California Retina Vitreous Associates Medical Group, Inc.

Mountain View, California, United States

Retina Consultants of Southern Colorado

Colorado Springs, Colorado, United States

RSC Research LLC

Denver, Colorado, United States

Retina Consultants of Southern Colorado

Pueblo, Colorado, United States

Connecticut Eye Consultants, P.C.

Danbury, Connecticut, United States

Retina Consultants, P.C.

Manchester, Connecticut, United States

Retina Group of New England

Waterford, Connecticut, United States

Retina Group of Florida

Fort Myers, Florida, United States

Florida Retina Institute

Orlando, Florida, United States

Retina Group of Florida (Site 065)

Sarasota, Florida, United States

Center for Retina and Macular Disease (Site 062)

Winter Haven, Florida, United States

Illinois Retina Associates

Joliet, Illinois, United States

University Retina & Macula Associates, P.C.

Lemont, Illinois, United States

Wolfe Eye Clinic

West Des Moines, Iowa, United States

Retina Associates, LLC

Lenexa, Kansas, United States

Butchertown Clinical Trials

Louisville, Kentucky, United States

Maine Eye Center (Site 097)

Portland, Maine, United States

Mid Atlantic Retina Specialists

Hagerstown, Maryland, United States

Retina Research Institute at New England Retina Consultants, PC

Springfield, Massachusetts, United States

Retina Consultants of Minnesota

Edina, Minnesota, United States

Envision Ocular, LLC

Bloomfield, New Jersey, United States

Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY

Great Neck, New York, United States

Retina Associates of Western NY, PC (Site 051)

Rochester, New York, United States

Asheville Eye Associates, Retina Division (Site 077)

Asheville, North Carolina, United States

NC Retina

Cary, North Carolina, United States

Graystone Eye

Hickory, North Carolina, United States

NC Retina Associates

Wake Forest, North Carolina, United States

Erie Retina Research

Erie, Pennsylvania, United States

Charleston Neuroscience Institute (Site 034)

Beaufort, South Carolina, United States

Palmetto Retina Center

Florence, South Carolina, United States

Charleston Neuroscience Institute

Ladson, South Carolina, United States

Palmetto Retina Center

West Columbia, South Carolina, United States

Southeastern Retina Associates

Hixson, Tennessee, United States

Southeastern Retina Associates (Site 095)

Johnson City, Tennessee, United States

Southeastern Retina Associates, P.C.

Knoxville, Tennessee, United States

Tennessee Retina

Nashville, Tennessee, United States

Retina Consultants of Texas

Bellaire, Texas, United States

Texas Retina Associates

Fort Worth, Texas, United States

Retina Consultants of Texas

Katy, Texas, United States

Austin Retina Associates

Round Rock, Texas, United States

Retina Consultants of Texas

San Antonio, Texas, United States

Austin Retina Associates

San Marcos, Texas, United States

Retina Consultants of Texas

Schertz, Texas, United States

Salt Lake Retina

West Jordan, Utah, United States

Vistar Eye Center (Site 129)

Roanoke, Virginia, United States

Pacific Northwest Retina

Bellevue, Washington, United States

IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia (Site 332)

São Paulo, Brazil

Clinica Oftalmologica del Caribe (COFCA)

Barranquilla, Colombia

Fundacion Oftalmologica Nacional

Bogotá, Colombia

Clinica de Oftalmologia Sandiego

Medellín, Colombia

Klaudians Hospital - Ophthalmology department

Mladá Boleslav, Czechia

VISUS spol. s r.o.

Náchod, Czechia

Axon Clinical, s.r.o. (Site 400)

Prague, Czechia

Hopital Intercommunal De Creteil

Créteil, France

View Full Details on ClinicalTrials.gov

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NCT07496567

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