RecruitingPhase 3NCT07499232

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

A Phase 3b, Multicenter, Randomized, Open-Label, Active-Controlled Study to Compare the Efficacy and Safety of Guselkumab Versus Risankizumab in the Treatment of Participants With Moderately to Severely Active Crohn's Disease

Sponsor

Janssen Research & Development, LLC

Enrollment

530 participants

Start Date

Apr 21, 2026

Study Type

INTERVENTIONAL

Conditions

Crohn Disease

Summary

The purpose of this study is to assess how well guselkumab works when compared to risankizumab in participants with moderately to severely active Crohn's Disease (CD; a long-term condition causing severe inflammation of the intestinal tract).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Guselkumab and a drug called Risankizumab for people with crohn disease. The study is currently recruiting participants at 30 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGuselkumab

Guselkumab will be administered.

DRUGRisankizumab

Risankizumab will be administered.

Locations(102)

Digestive Health Specialists of the Southeast

Dothan, Alabama, United States

East View Medical Research

Mobile, Alabama, United States

Clinnova Research

Anaheim, California, United States

United Gastroenterologists

Los Alamitos, California, United States

TLC Clinical Research Inc

Los Angeles, California, United States

Hoag Memorial Hospital

Newport Beach, California, United States

Medical Associates Research Group, Inc.

San Diego, California, United States

Peak Gastroenterology Associates

Colorado Springs, Colorado, United States

Medical Research Center of Connecticut

Hamden, Connecticut, United States

Green Leaf Clinical Trials

Jacksonville, Florida, United States

Sanchez Clinical Research, Inc

Miami, Florida, United States

GCP Clinical Research

Tampa, Florida, United States

Gastroenterology Associates of Central GA

Macon, Georgia, United States

Cotton-O'Neil Clinical Research Center

Topeka, Kansas, United States

Gastroenterology Clinic of Acadiana

Lafayette, Louisiana, United States

Westchester Putnam Gastroenterology

Carmel, New York, United States

New York Gastroenterology Associates

New York, New York, United States

Charlotte Gastroenterology and Hepatology, PLLC

Charlotte, North Carolina, United States

Great Lakes Gastroenterology Research, LLC

Mentor, Ohio, United States

Digestive Disease Specialists Inc

Oklahoma City, Oklahoma, United States

Frontier Clinical Research

Uniontown, Pennsylvania, United States

Palmetto Primary and Specialty Care Physicians, Charleston

Summerville, South Carolina, United States

DFW Clinical Trials

Carrollton, Texas, United States

Lubbock Gastroenterology

Lubbock, Texas, United States

Southern Star Research Institute, LLC

San Antonio, Texas, United States

Medizinische Universitatsklinik Innsbruck

Innsbruck, Austria

LKH - Universitätsklinikum der PMU Salzburg

Salzburg, Austria

Klinikum Wels Grieskirchen

Wels, Austria

Ziekenhuis Oost-Limburg

Genk, Belgium

Ghent University Hospital

Ghent, Belgium

Universitair Ziekenhuis Leuven

Leuven, Belgium

Algemeen Ziekenhuis Delta

Roeselare, Belgium

GIRI Gastrointestinal Research Institute

Vancouver, British Columbia, Canada

Charlton Digestive Disease Centre

Hamilton, Ontario, Canada

London Digestive Disease Institute

London, Ontario, Canada

Taunton Surgical Centre

Oshawa, Ontario, Canada

Toronto Immune and Digestive Health Institute Inc

Toronto, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, Canada

Clinique IMD

Montreal, Quebec, Canada

The Sixth Affiliated Hospital Sun Yat sen University

Guangzhou, China

Vojenska nemocnice Brno

Brno, Czechia

Gastroenterologie, s.r.o., Hradec Kralove

Hradec Kralova, Czechia

Hepato-gastroenterologie HK, s.r.o.

Hradec Králové, Czechia

Fakultni Nemocnice Ostrava

Ostrava-Poruba, Czechia

Fakultni nemocnice Kralovske Vinohrady

Prague, Czechia

Fakultni Thomayerova nemocnice

Prague, Czechia

Aarhus University Hospital

Aarhus C, Denmark

Sydvestjysk Sygehus

Esbjerg, Denmark

NAU New Aalborg University Hospital

Gistrup, Denmark

Herlev Hospital

Herlev, Denmark

Nordsjaellands Hospital, Hillerod

Hilleroed, Denmark

Hvidovre Hospital

Hvidovre, Denmark

Bispebjerg Hospital

København NV, Denmark

Odense UH og Svendberg sygehus

Odense C, Denmark

CHU Amiens Picardie

Amiens, France

Clermont Ferrand University Hospital

Clermont-Ferrand, France

Aphm - Hopital Nord

Marseille, France

CHU Nantes - Hotel Dieu

Nantes, France

Clinique Ambroise Pare

Neuilly-sur-Seine, France

CHU Nimes

Nîmes, France

Aphp Hopital Saint Antoine

Paris, France

Centre Hospitalier Universitaire de Nancy - Hôpital Central

Vandœuvre-lès-Nancy, France

GASTRO-Studien

Berlin, Germany

Praxiszentrum Fur Gastroenterologie und Endoskopie Grevenbroich

Grevenbroich, Germany

Universitatsklinikum Jena

Jena, Germany

Klinikum rechts der Isar der TU Munchen

München, Germany

Radboud Umcn

Nijmegen, Netherlands

St. Elisabeth Ziekenhuis

Tilburg, Netherlands

Centrum Medyczne Medis ManerMed Sp Z O O

Bydgoszcz, Poland

Centrum Medyczne Plejady

Krakow, Poland

Centrum Medyczne Promed

Krakow, Poland

Centrum Medyczne 'Medyk' Sp. z o.o. K.

Rzeszów, Poland

Twoja Przychodnia - Szczecinskie Centrum Medyczne

Szczecin, Poland

GASTROMED Kopon Zmudzinski i wspolnicy SP j Specjalistyczne Centrum Gastrologii i Endoskopii

Torun, Poland

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy

Warsaw, Poland

Medical Network Sp z o o

Warsaw, Poland

FNsP F. D. Roosevelta Banska Bystrica

Banská Bystrica, Slovakia

Cliniq s.r.o.

Bratislava, Slovakia

ENDOMED s.r.o

Košice, Slovakia

Fakultna nemocnica s poliklinikou Nove Zamky

Nové Zámky, Slovakia

GASTRO I. s.r.o.

Prešov, Slovakia

Gastro LM s.r.o.

Prešov, Slovakia

Hosp. Clinic de Barcelona

Barcelona, Spain

Hosp. Arquitecto Marcide

Ferrol, Spain

Hosp. Univ. Dr. Josep Trueta

Girona, Spain

Hosp. Univ. de Torrejon

Madrid, Spain

Hosp. de Navarra

Navarra, Spain

Hosp. Clinico Univ. de Santiago

Santiago de Compostela, Spain

Hosp. Virgen Macarena

Seville, Spain

Linkoping University Hospital

Linköping, Sweden

Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus

Mölndal, Sweden

Ersta sjukhus

Stockholm, Sweden

Sodersjukhuset

Stockholm, Sweden

Karolinska Universitetssjukhuset

Stockholm, Sweden

Akademiska Sjukhuset

Uppsala, Sweden

Barts Health NHS Trust

Greater London, United Kingdom

London North West University Healthcare NHS Trust

Greater London, United Kingdom

University College London Hospitals Nhs Foundation Trust

London, United Kingdom

Chelsea And Westminster Hospital

London, United Kingdom

Imperial College London

London, United Kingdom

Norfolk and Norwich University Hospital

Norwich, United Kingdom

New Cross Hospital

Wolverhampton, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07499232

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