Effect of Morus Nigra Mouthwash on Gingivitis Treatment
Evaluation of the Efficacy of Morus Nigra Mouthwash as an Adjunct to Scaling and Root Planing in the Treatment of Gingivitis: A Randomized Controlled Trial
Inonu University
30 participants
Jan 15, 2026
INTERVENTIONAL
Conditions
Summary
The aim of this study is to evaluate the clinical, microbiological, and biochemical effects of Morus nigra (black mulberry) mouthwash when used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with generalized gingivitis. Participants will be randomly assigned to two groups: one receiving SRP only, and the other receiving SRP plus Morus nigra mouthwash twice daily for 14 days. Clinical parameters, cytokine levels in gingival crevicular fluid (TNF-alpha, IL-1beta, IL-10), and subgingival bacterial load will be assessed at baseline, 1 month, and 3 months.
Eligibility
Inclusion Criteria4
- Diagnosis of generalized gingivitis (Gingival Index \> 1).
- Presence of at least 20 natural teeth.
- Systemically healthy individuals.
- Ability to provide informed consent.
Exclusion Criteria6
- Smoking or use of tobacco products.
- Presence of periodontitis (no clinical attachment loss).
- Use of antibiotics or anti-inflammatory drugs in the last 6 months.
- Pregnancy or lactation.
- History of allergy to Morus nigra or mouthwash components.
- Systemic diseases (Diabetes, cardiovascular diseases, etc.).
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Interventions
Mechanical removal of dental plaque and calculus from the tooth surfaces
Morus nigra extract based mouthwash, used 2 times a day for 14 days
Locations(1)
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NCT07499596