RecruitingNot ApplicableNCT07512154

Precision Radiotherapy Enabled by Molecular MRI

Sponsor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Enrollment

20 participants

Start Date

Apr 29, 2026

Study Type

INTERVENTIONAL

Conditions

Brain Cancer

Summary

This is a research study to determine if a novel molecular magnetic resonance imaging (MRI) technique, called amide proton transfer (APT) imaging, is useful in identifying the most aggressive areas of tumor needed for radiotherapy of brain tumors.

Eligibility

Min Age: 18 Years

Inclusion Criteria13

Histologic confirmation of glioblastoma or grade 4 astrocytoma
Age >18
KPS at least 60
Patients must have normal organ and marrow function as defined below:
leukocytes >3,000/mcL
absolute neutrophil count >1,500/mcL
platelets >100,000/mcL
total bilirubin within normal institutional limits
AST(SGOT)/ALT(SGPT) <2.5
institutional upper limit of normal
creatinine within normal institutional limits OR creatinine clearance >60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal.
Patients of child-bearing potential (male or female) must practice adequate contraception due to possible harmful effects of radiation therapy on an unborn child.
Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria5

Patients who are unable to receive MRIs will be excluded from the study.
Patients may not be receiving any other investigational cancer treatment agents at the time of enrollment.
Patients may not have previously been treated with an overlapping course of radiotherapy to the brain.
Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Pregnant and/or breastfeeding women are excluded. Women of child-bearing potential who are unwilling or unable to use an acceptable method of birth control to avoid pregnancy for the entire study period and up to 12 weeks after the study are excluded. Male subjects must also agree to use effective contraception for the same period as above.

Interested in this trial?

Get notified about updates and connect with the research team.