Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

This study is testing a surgical approach in patients with glioblastoma (an aggressive brain tumor) that involves placing a specialized tissue flap during surgery to help chemotherapy bypass the blood-brain barrier — the natural shield around the brain that often blocks cancer drugs from reaching tumors effectively. **You may be eligible if...** - You are 18 or older and are scheduled for surgery to remove a known or suspected glioblastoma - Your tumor can likely be removed by at least 80% - Your overall performance level (Karnofsky score ≥70%) and organ function are adequate - Your expected survival is at least 6 months **You may NOT be eligible if...** - You have already started chemotherapy or radiation for glioblastoma - You are planning to use a specific biodegradable chemotherapy wafer (Gliadel) during surgery - You have an active infection - You have cancer that has spread to multiple sites in the brain or spinal fluid - You have had another cancer and are not cancer-free for at least 5 years (with some exceptions) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.