RecruitingNCT07518966

Association Between Early Recurrence and Long-Term Recurrence After Pulsed Field Ablation for Atrial Fibrillation: Prospective Real-World Evidence From China


Sponsor

West China Hospital

Enrollment

1,200 participants

Start Date

Jun 16, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to analyze the predictive value of early recurrence within different time windows for late recurrence, ultimately providing evidence-based support for defining the blanking period after pulsed field ablation and stratifying recurrence risk, with the goal of transforming clinical management strategies following pulsed field ablation. The main questions it aims to answer are: 1. Employ big data analysis methods to develop a risk stratification tool for atrial fibrillation; 2. Identify high-risk prognostic indicators for atrial fibrillation and establish early assessment models for short-term and long-term prognosis. Participants will undergo pulsed field ablation for the treatment of atrial fibrillation and will receive structured follow-ups at 1, 3, 6, and 12 months post-ablation. At each follow-up, a 24-hour Holter monitor will be performed to systematically assess the recurrence of atrial arrhythmias and the atrial arrhythmia burden.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Patients aged ≥18 years
  • Study participants diagnosed with atrial fibrillation (AF) and scheduled to undergo pulsed field ablation
  • Study participants undergoing their first ablation procedure for AF

Exclusion Criteria2

  • Study participants with any known contraindications to the pulsed field ablation system, anticoagulation therapy, use of contrast agents, or atrial fibrillation ablation
  • Those who have previously undergone atrial fibrillation ablation, or have severe mitral stenosis, valve replacement, or various cardiac surgeries.

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Interventions

PROCEDUREpulsed field ablation

The patient underwent the ablation procedure using the pentaspline pulsed field ablation system.


Locations(1)

West China Hospital, Sichuan University

Chengdu, Sichuan, China

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NCT07518966


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