RecruitingNCT07531966

Vascular Complications After Kidney Transplantation

Vascular Complications After Kidney Transplantation: A Prospective National Multicenter Study - The DAN-PTRAIII Study

Sponsor

University of Aarhus

Enrollment

60 participants

Start Date

May 22, 2026

Study Type

OBSERVATIONAL

Conditions

Heart Failure Kidney Transplant; Complications Renovascular Hypertension Kidney Transplant Recipient Transplant Renal Artery Stenosis Renovascular Disease Renal Transplant Graft Failure

Summary

* To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients in Denmark are evaluated according to uniform, well-defined clinical criteria. * To investigate the efficacy and safety of catheter-based balloon treatment (percutaneous transluminal angioplasty, PTA) for these vascular complications, of which transplant renal artery stenosis is by far the most common. * To assess whether novel imaging and functional diagnostic methods can predict treatment response.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Catheter-based angiography, Intravascular ultrasound (IVUS), and others for people with heart failure, kidney transplant recipient, and other related conditions. The study is currently recruiting participants at 3 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTCatheter-based angiography

Catheter-based angiography performed in accordance with the study protocol.

DIAGNOSTIC_TESTMeasurement of translesional pressure gradients

Measurement of translesional pressure gradients performed in accordance with the study protocol.

DIAGNOSTIC_TESTIntravascular ultrasound (IVUS)

Intravascular ultrasound (IVUS) performed in accordance with the study protocol.

PROCEDUREPercutaneous transluminal angioplasty (PTA)

Percutaneous transluminal angioplasty (PTA) is performed in accordance with the study protocol. As a general principle, bare-metal stents (BMS) are used. Drug-eluting stents (DES) may be considered when the arterial lumen diameter is \< 4-5 mm. In stenoses where stent placement carries a risk of side-branch occlusion, PTA is performed without stent implantation and most often with a drug-coated balloon (DCB).