RecruitingNCT07535177

Gas6 and Soluble MerTK in Periodontal Diseases

Evaluation of Gas6 and Soluble MerTK Levels in Gingival Crevice Fluid in Individuals With Periodontal Health, Gingivitis, and Periodontitis

Sponsor

Abant Izzet Baysal University

Enrollment

90 participants

Start Date

Mar 25, 2026

Study Type

OBSERVATIONAL

Conditions

Periodontitis

Summary

This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
Individuals who have not used antibiotics within the last 3 months
Individuals not taking any medications known to affect periodontal tissues
Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
Individuals with at least 16 natural teeth, excluding third molars
Individuals aged 18 years and older

Exclusion Criteria3

Pregnant or lactating individuals
Individuals who have received periodontal treatment within the last 6 months
Current smokers

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERgingival crevicular fluid collection

Gingival crevicular fluid collection using sterile paper strips inserted into the gingival sulcus for 30 seconds from selected periodontal sites (healthy, gingivitis, and periodontitis) for biomarker analysis (Gas6 and sMerTK).