Periodontitis Clinical Trials

107 recruiting

Periodontitis Trials at a Glance

132 actively recruiting trials for periodontitis are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 91 trials, with the heaviest enrollment activity in Rohtak, Hangzhou, and Cairo. Lead sponsors running periodontitis studies include Postgraduate Institute of Dental Sciences Rohtak, Assistance Publique - Hôpitaux de Paris, and Abant Izzet Baysal University.

Browse periodontitis trials by phase

Treatments under study

About Periodontitis Clinical Trials

Looking for clinical trials for Periodontitis? There are currently 107 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Periodontitis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Periodontitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 132 trials

Recruiting

Performance of the Treatment of Periodontitis According to the Bioperio® Protocol

Periodontitis
University of Pisa5,000 enrolled1 locationNCT07507474
Recruiting
Not Applicable

Active Oxygen Releasing Gel With Photodynamic Therapy in Treating Stage III Periodontitis

Stage III Periodontitis
Alexandria University42 enrolled1 locationNCT07368699
Recruiting

ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE

GingivitisPeriodontal DiseasesPeriodontitis
Abant Izzet Baysal University160 enrolled1 locationNCT07530978
Recruiting

Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)

GingivitisPeriodontitisPeriodontal Disease
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University2,000 enrolled3 locationsNCT07406867
Recruiting
Not Applicable

A Clinical Trial Comparing 2x/Day for 30-minutes Use of the Emanate Perio PODS Post-SRP to a Control Group Post-SRP.

Periodontitis (Stage 3)
McGuire Institute72 enrolled9 locationsNCT06914596
Recruiting

Oral Microbiome in Carotid Atherosclerosis

PeriodontitisAtherosclerosis Cardiovascular DiseaseAtherosclerosis of Artery+2 more
Semmelweis University Heart and Vascular Center200 enrolled1 locationNCT07296965
Recruiting
Not Applicable

Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis

Periodontitis
Al-Mustansiriyah University44 enrolled2 locationsNCT07547202
Recruiting

Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax

PeriodontitisGingivitis and Periodontal Diseases
Abant Izzet Baysal University120 enrolled1 locationNCT07551115
Recruiting

Discovery and Validation of Periodontitis Biomarkers

PeriodontitisBiomarker in Early DiagnosisSaliva
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University228 enrolled1 locationNCT07293481
Recruiting
Not Applicable

Is Professional Tooth Cleaning Necessary for Managing Gingivitis (Gingival Inflammation) if Subjects Use Intelligent Toothbrushes?

GingivitisPeriodontitis
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University92 enrolled1 locationNCT07549347
Recruiting
Not Applicable

The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.

PeriodontitisBone Defects
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio40 enrolled1 locationNCT07546279
Recruiting
Not Applicable

Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects

Periodontitis
University of Sao Paulo66 enrolled1 locationNCT07522684
Recruiting
Not Applicable

In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers

Chronic Apical Periodontitis
The Dental Hospital of Zhejiang University School of Medicine160 enrolled1 locationNCT07388901
Recruiting

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

Periodontal DiseasesPeriodontitis
University of Chile30 enrolled1 locationNCT07536204
Recruiting

Gas6 and Soluble MerTK in Periodontal Diseases

Periodontitis
Abant Izzet Baysal University90 enrolled1 locationNCT07535177
Recruiting
Not Applicable

Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients

PeriodontitisKidney Transplant Recipients
Military Hospital 10380 enrolled2 locationsNCT07532694
Recruiting
Not Applicable

Probiotics as Adjunctive Therapy in the Management of Periodontitis

Periodontitis
University of Malaya20 enrolled1 locationNCT07531875
Recruiting

Application of Ultra-high Frequency Ultrasonography (UHFUS) to the Study of Gingival Tissues

GingivitisPeriodontitis
University of Pisa40 enrolled2 locationsNCT06480825
Recruiting
Not Applicable

Hyaluronic Acid in Endodontic Microsurgery

Periapical Periodontitis
University of Bern46 enrolled1 locationNCT07501585
Recruiting

Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features

Aggressive PeriodontitisPeriodontis
Second Affiliated Hospital, School of Medicine, Zhejiang University9 enrolled1 locationNCT07487272