Periodontitis Clinical Trials

156 recruitingLast updated: June 18, 2026

There are 156 actively recruiting periodontitis clinical trials across 43 countries. Studies span Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1. Top locations include Rohtak, Haryana, India, Cairo, Egypt, Hangzhou, Zhejiang, China. Updated daily from ClinicalTrials.gov.


Periodontitis Trials at a Glance

156 actively recruiting trials for periodontitis are listed on ClinicalTrialsFinder across 6 cities in 43 countries. The largest study group is Not Applicable with 103 trials, with the heaviest enrollment activity in Rohtak, Cairo, and Hangzhou. Lead sponsors running periodontitis studies include Postgraduate Institute of Dental Sciences Rohtak, Cairo University, and Assistance Publique - Hôpitaux de Paris.

Browse periodontitis trials by phase

Treatments under study

About Periodontitis Clinical Trials

Looking for clinical trials for Periodontitis? There are currently 115 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Periodontitis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Periodontitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 156 trials

Recruiting
Not Applicable

Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools

DiagnosisGingivitisPeriodontitis+1 more
CHU de Reims30 enrolled1 locationNCT06006429
Recruiting
Phase 2Phase 3

Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial

developmental delayGingivitisPeriodontitis+2 more
University of Washington6,000 enrolled1 locationNCT07424846
Recruiting
Not Applicable

The Effect of Different Intracanal Medicaments on Periapical Lesion Healing

Apical periodontitisPeriapical Lesion Healing
Mustafa Kemal University60 enrolled1 locationNCT07237620
Recruiting

Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy

Periodontitis
Recep Tayyip Erdogan University Training and Research Hospital100 enrolled1 locationNCT07287540
Recruiting
Not Applicable

Rotary Versus Manual Degranulation in Alveolar Ridge Preservation

Alveolar Ridge PreservationChronic Periapical Periodontitis
Imam Abdulrahman Bin Faisal University60 enrolled1 locationNCT07607314
Recruiting
Not Applicable

Responsiveness of Hindi Version of Oral Health Impact Profile for Periodontitis (OHIP-P-HIN)

PeriodontitisOral Health Quality of Life (OHQoL) Was Assessed
Postgraduate Institute of Dental Sciences Rohtak106 enrolled1 locationNCT07304596
Recruiting
Not Applicable

Impact of Periodontal Inflammation on Allostatic Load

Allostatic LoadPeriodontitis, Chronic
Postgraduate Institute of Dental Sciences Rohtak112 enrolled1 locationNCT06978712
Recruiting
Early Phase 1

The Effect of Different Intra-canal Medications on Postoperative Pain

Pulp Necrosis, Apical Periodontitis
Cairo University111 enrolled1 locationNCT07603934
Recruiting
Phase 4

Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial

Apical periodontitis
TC Erciyes University100 enrolled1 locationNCT07599254
Recruiting
Not Applicable

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

Gum diseasePeriodontal DiseasesPeriodontitis
Erchonia Corporation70 enrolled2 locationsNCT06656325
Recruiting
Not Applicable

Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis

PeriodontitisPeriodontitis Stage IIPeriodontitis Stage III
Cairo University18 enrolled1 locationNCT07599657
Recruiting
Not Applicable

Electrolysed Saline Rinse as an Adjunct for Treatment of Chronic Periodontitis

Periodontitis
University of Ljubljana60 enrolled1 locationNCT06692582
Recruiting

Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax

PeriodontitisGingivitis and Periodontal Diseases
Abant Izzet Baysal University120 enrolled1 locationNCT07551115
Recruiting

PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY

PeriodontitisMyocardial Infarction, Acute
University of Aberdeen320 enrolled1 locationNCT04719026
Recruiting

Candida Albicans in Syrian Patients With Periodontitis

Periodontal DiseasesPeriodontitisPeriodontal Disease
Al-Hawash Private University100 enrolled1 locationNCT07574827
Recruiting
Not Applicable

Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning

Apical periodontitisperiodontal inflammationMRI+2 more
University of Aarhus470 enrolled1 locationNCT05439330
Recruiting

Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population Using Semi-Supervised Learning

GingivitisPeriodontal DiseasesPeriodontitis
Universiti Sains Malaysia393 enrolled1 locationNCT07410351
Recruiting
Not Applicable

MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery

PeriodontitisPeriimplantitis
University Hospital Muenster84 enrolled1 locationNCT07414498
Recruiting

Performance of the Treatment of Periodontitis According to the Bioperio® Protocol

Periodontitis
University of Pisa5,000 enrolled1 locationNCT07507474
Recruiting
Not Applicable

Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity

ObesityPeriodontitis
University of Sao Paulo24 enrolled1 locationNCT06073704