RecruitingNCT07539675
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Sponsor
Zhongnan Hospital
Enrollment
150 participants
Start Date
Oct 1, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Eligibility
Min Age: 50 Years
Inclusion Criteria5
- Clinically diagnosed with primary angle-closure glaucoma (PACG)
- Aged ≥ 50 years, no gender restriction
- Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
- Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
- Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Exclusion Criteria5
- Secondary glaucoma
- History of previous intraocular surgery
- Systemic diseases that can cause abnormal ocular zonules
- Other severe ocular diseases
- Long-term use of medications affecting connective tissue metabolism
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Interventions
OTHERNo Additional Experimental Intervention
No Additional Experimental Intervention
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07539675
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