Cardiac Surgery Clinical Trials

61 recruiting

Cardiac Surgery Trials at a Glance

108 actively recruiting trials for cardiac surgery are listed on ClinicalTrialsFinder across 6 cities in 34 countries. The largest study group is Not Applicable with 37 trials, with the heaviest enrollment activity in Toronto, Beijing, and Berlin. Lead sponsors running cardiac surgery studies include Assistance Publique - Hôpitaux de Paris, Centre Hospitalier Universitaire, Amiens, and Prince of Wales Hospital.

Browse cardiac surgery trials by phase

Treatments under study

About Cardiac Surgery Clinical Trials

Looking for clinical trials for Cardiac Surgery? There are currently 61 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cardiac Surgery trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cardiac Surgery clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 108 trials

Recruiting
Not Applicable

Parasternal vs. Combined Parasternal-Serratus Block in Cardiac Surgery

Postoperative PainCardiac Surgery
BEDİA MİNE HANEDAN70 enrolled1 locationNCT07522229
Recruiting
Not Applicable

SPSIP Block and Opioid Use After MICS

Postoperative Pain ManagementSerratus Posterior Superior Intercostal Plane BlockHeart Valvular Disease+1 more
Ankara City Hospital Bilkent50 enrolled1 locationNCT07259824
Recruiting

Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery

Venous CongestionMicrocirculatory DiffusionMicrocirculatory Convection Capacity+1 more
University Hospital, Basel, Switzerland40 enrolled1 locationNCT07052461
Recruiting
Phase 3

Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery

Bariatric SurgeryCardiac Surgery With Sternotomy
Icahn School of Medicine at Mount Sinai235 enrolled1 locationNCT07539623
Recruiting
Not Applicable

Ultra Fast-Track vs Fast-Track Protocols in Off-Pump and Minimally Invasive Valve Cardiac Surgery

Cardiac Surgery
Azienda Socio Sanitaria Territoriale Ovest Milanese, Ospedale di Legnano50 enrolled1 locationNCT07518524
Recruiting
Not Applicable

Long-term Outcomes Sub-Study of Preoperative Combined Iron Therapy

Iron DeficienciesAnemiaCardiac Surgery
Second Affiliated Hospital, School of Medicine, Zhejiang University400 enrolled1 locationNCT06968936
Recruiting

The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery

Postoperative Neurocognitive DisorderElderly PatientsCardiac Surgery+4 more
Ziekenhuis Oost-Limburg80 enrolled1 locationNCT07200726
Recruiting
Phase 1Phase 2

Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children

Mechanical VentilationCongenital Heart DiseaseChildren+8 more
Charite University, Berlin, Germany80 enrolled1 locationNCT07193719
Recruiting
Not Applicable

Objective Measurement of the Mechanical Pain Threshold With an Algometer for Predicting Intraoperative Opioid Consumption in Patients Who Will be Operate by Thoracotomy and Sternotomy in Cardiac Surgery

Cardiac Surgery Subjects
Université Libre de Bruxelles100 enrolled1 locationNCT07513974
Recruiting

Investigation of Sedation Depth Via BIS Monitoring in ICU After Cardiac Surgery

Sedation After Cardiac Surgery
Medical University of Graz50 enrolled2 locationsNCT07350109
Recruiting

Venous Congestion And Cognitive Dysfunction After Cardiac Surgery

Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Zhuan Zhang110 enrolled1 locationNCT07483151
Recruiting
Phase 4

Effect of Intraoperative Morphine on Postoperative Pain After CABG

Postoperative PainPain After SurgeryCardiac Surgery Patient
Istanbul University - Cerrahpasa60 enrolled1 locationNCT07472959
Recruiting
Not Applicable

Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) in the Management of Postoperative Sternotomy Pain in Patients Undergoing Cardiac Surgery Via Sternotomy

Pain ManagementPostoperative PainCardiac Surgery+2 more
Uludag University50 enrolled1 locationNCT07472296
Recruiting
Phase 4

Intrapleural Ropivacaine Infusion in Cardiac Surgery

Coronary Artery DiseaseCardiac SurgeryValvular Diseases
Saint Petersburg State University, Russia116 enrolled2 locationsNCT07116343
Recruiting
Not Applicable

Safety of the IPERF Femoral Arterial Cannula in Patients Undergoing Planned Cardiac Surgery With Extracorporeal Circulation Via Femoral Approach

Cardiac SurgeryIschemia Limb
IPERF SAS15 enrolled2 locationsNCT07163234
Recruiting
Not Applicable

Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.

Congenital Heart Disease (CHD)Postoperative Respiratory DysfunctionPostoperative Recovery After Cardiac Surgery
University of Baghdad99 enrolled4 locationsNCT07405333
Recruiting
Not Applicable

Diagnosis of Postoperative Atrial Fibrillation by a Smartwatch

Atrial FibrillationCardiac Surgery
Centre Hospitalier Universitaire, Amiens324 enrolled1 locationNCT05573633
Recruiting
Phase 2

Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients

Coronary Artery Bypass Grafting (CABG)Cardiopulmonary BypassIntensive Care Unit+9 more
GCP-Service International West GmbH550 enrolled10 locationsNCT06279793
Recruiting
Not Applicable

Transversus Thoracic Muscle Plane Block Versus Pectointercostal Fascial Block for Enhanced Recovery After Cardiac Surgery

Cardiac SurgeryTransversus Thoracic Muscle Plane BlockPecto-intercostal Fascial Block+1 more
Assiut University90 enrolled1 locationNCT07417462
Recruiting
Not Applicable

Telemedically Assisted Optimization for Heart Failure Patients Before Cardiac Surgery to Improve Perioperative Outcome

Patients With Heart Failure Undergoing Cardiac Surgery
Medical University Innsbruck162 enrolled1 locationNCT07391683