Cardiac Surgery Clinical Trials

155 recruitingLast updated: July 17, 2026

There are 155 actively recruiting cardiac surgery clinical trials across 37 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1, Phase 1. Top locations include Toronto, Ontario, Canada, Amiens, France, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Cardiac Surgery Trials at a Glance

155 actively recruiting trials for cardiac surgery are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 55 trials, with the heaviest enrollment activity in Toronto, Amiens, and Beijing. Lead sponsors running cardiac surgery studies include Centre Hospitalier Universitaire, Amiens, Seoul National University Hospital, and Assistance Publique - Hôpitaux de Paris.

Browse cardiac surgery trials by phase

Treatments under study

About Cardiac Surgery Clinical Trials

Looking for clinical trials for Cardiac Surgery? There are currently 76 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cardiac Surgery trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cardiac Surgery clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 155 trials

Recruiting
Phase 2

Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients

Coronary Artery Bypass Grafting (CABG)Cardiopulmonary BypassIntensive Care Unit+9 more
GCP-Service International West GmbH550 enrolled10 locationsNCT06279793
Recruiting
Not Applicable

Individualized Versus Conventional Perioperative Blood Pressure Management

Major non-cardiac surgery
Seoul National University Hospital1,896 enrolled5 locationsNCT06225453
Recruiting
Not Applicable

Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery

Cardiac SurgeryPost Operative Pain, Acute
Ondokuz Mayıs University50 enrolled1 locationNCT07164677
Recruiting
Not Applicable

SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older

FrailtyCardiac SurgeryQALYs
University Hospital, Bordeaux265 enrolled1 locationNCT07677319
Recruiting
Phase 2

A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)

Cardiac Surgery associated Acute kidney injuryIschemia Reperfusion Injury
Bilix Co.,Ltd.50 enrolled8 locationsNCT07164833
Recruiting

HEMO-INTEGRA: Integrated Intraoperative Hemodynamic Monitoring During Cardiac Surgery With Cardiopulmonary Bypass - A Pilot Study

Hemodynamic MonitoringCardiac SurgeryCardiopulmonary Bypass+1 more
Hernán Darío Castro Arias30 enrolled1 locationNCT07683299
Recruiting
Not Applicable

A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine

Cardiac Surgery associated Acute kidney injury
Bayer200 enrolled4 locationsNCT06772025
Recruiting

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Atrial FibrillationCardiac Surgery
Brigham and Women's Hospital150 enrolled1 locationNCT04880265
Recruiting

Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome

Cardiac SurgeryExtracorporeal Circulation
University Hospital, Toulouse120 enrolled1 locationNCT06840327
Recruiting
Phase 4

Colchicine's Effect on Inflammatory Markers

ColchicinePost-operative Atrial FibrillationInflammation in Cardiac Surgery+2 more
Ayesha Ather24 enrolled1 locationNCT07287345
Recruiting
Not Applicable

MedlyPeds Feasibility Study

Post-cardiac surgeryPulmonary HypertensionCongenital Heart Disease (CHD)+2 more
The Hospital for Sick Children30 enrolled1 locationNCT07556185
Recruiting

Perioperative Continuous Glucose Monitoring Accuracy in Cardiac Surgery

Cardiac Surgery
Seoul National University Hospital100 enrolled1 locationNCT07385170
Recruiting
Phase 4

Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications

Cardiac Surgery
Seoul National University Hospital1,292 enrolled4 locationsNCT07410988
Recruiting
Not Applicable

Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy

Cardiac Surgery
Beni-Suef University138 enrolled1 locationNCT05885230
Recruiting

Prediction Model for MINS After Major Hepatobiliary Surgery

Postoperative ComplicationsLiver NeoplasmMyocardial Injury After Noncardiac Surgery (MINS)+1 more
Beijing Tsinghua Chang Gung Hospital1,800 enrolled6 locationsNCT07335042
Recruiting
Phase 2

LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Acute Kidney InjuryCardiac Surgery
Arch Biopartners Inc.240 enrolled9 locationsNCT05879432
Recruiting
Not Applicable

COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial

On-pump Cardiac SurgeryHigh Risk for BleedingAutotransfusion
University Hospital, Bordeaux570 enrolled10 locationsNCT06425614
Recruiting

Cardiac Surgery, the Incidence and Impact of Chronic postOperative Pain: a Survey

Cardiac SurgeryChronic Postoperative Pain
Universitaire Ziekenhuizen KU Leuven1,000 enrolled1 locationNCT07640646
Recruiting

CARE Qualitative Study

Cardiac Surgery
University Hospitals Bristol and Weston NHS Foundation Trust24 enrolled1 locationNCT07611045
Recruiting
Phase 3

Hydrocortisone Plus Fludrocortisone in High-risk Patients Undergoing for Cardiac Surgery

Inflammation in Cardiac Surgery
Centre Hospitalier Universitaire, Amiens196 enrolled1 locationNCT07037043