Cardiac Surgery Clinical Trials

149 recruitingLast updated: June 18, 2026

There are 149 actively recruiting cardiac surgery clinical trials across 37 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1, Phase 1. Top locations include Toronto, Ontario, Canada, Amiens, France, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Cardiac Surgery Trials at a Glance

149 actively recruiting trials for cardiac surgery are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 53 trials, with the heaviest enrollment activity in Toronto, Amiens, and Beijing. Lead sponsors running cardiac surgery studies include Centre Hospitalier Universitaire, Amiens, Assistance Publique - Hôpitaux de Paris, and Prince of Wales Hospital.

Browse cardiac surgery trials by phase

Treatments under study

About Cardiac Surgery Clinical Trials

Looking for clinical trials for Cardiac Surgery? There are currently 71 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cardiac Surgery trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cardiac Surgery clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 149 trials

Recruiting

Prediction Model for MINS After Major Hepatobiliary Surgery

Postoperative ComplicationsLiver NeoplasmMyocardial Injury After Noncardiac Surgery (MINS)+1 more
Beijing Tsinghua Chang Gung Hospital1,800 enrolled6 locationsNCT07335042
Recruiting
Phase 2

LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Acute Kidney InjuryCardiac Surgery
Arch Biopartners Inc.240 enrolled9 locationsNCT05879432
Recruiting
Not Applicable

COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial

On-pump Cardiac SurgeryHigh Risk for BleedingAutotransfusion
University Hospital, Bordeaux570 enrolled10 locationsNCT06425614
Recruiting

Cardiac Surgery, the Incidence and Impact of Chronic postOperative Pain: a Survey

Cardiac SurgeryChronic Postoperative Pain
Universitaire Ziekenhuizen KU Leuven1,000 enrolled1 locationNCT07640646
Recruiting
Phase 4

Colchicine's Effect on Inflammatory Markers

ColchicinePost-operative Atrial FibrillationInflammation in Cardiac Surgery+2 more
Ayesha Ather24 enrolled1 locationNCT07287345
Recruiting

CARE Qualitative Study

Cardiac Surgery
University Hospitals Bristol and Weston NHS Foundation Trust24 enrolled1 locationNCT07611045
Recruiting
Phase 3

Hydrocortisone Plus Fludrocortisone in High-risk Patients Undergoing for Cardiac Surgery

Inflammation in Cardiac Surgery
Centre Hospitalier Universitaire, Amiens196 enrolled1 locationNCT07037043
Recruiting
Not Applicable

Upper Extremity Exercises With and Without Deep Breathing After Cardiac Surgery

Cardiac Surgery
Kocaeli University90 enrolled1 locationNCT07627009
Recruiting
Not Applicable

A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine

Cardiac Surgery associated Acute kidney injury
Bayer200 enrolled4 locationsNCT06772025
Recruiting
Not Applicable

The Effect of Combined Iron Protocols on Perioperative Allogeneic Transfusion

TransfusionAnemiaIron-Deficiency Anemia+2 more
Second Affiliated Hospital, School of Medicine, Zhejiang University400 enrolled1 locationNCT06012760
Recruiting
Not Applicable

Non-interventional Study Exploring the Composition of the Valvular Microbiota of Patients Undergoing Cardiac Surgery

MicrobiotaCardiac SurgeryValvulopathy
University Hospital, Toulouse200 enrolled1 locationNCT07075601
Recruiting
Phase 3

Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass

Cardiac SurgeryCardiopulmonary BypassNitric Oxide+1 more
Xijing Hospital3,650 enrolled3 locationsNCT06702553
Recruiting
Phase 4

The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

Acute Kidney Injury (AKI)AnesthesiaMyocardial Injury After Noncardiac Surgery (MINS)+4 more
University of California, San Francisco18,000 enrolled10 locationsNCT06802224
Recruiting

Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients

Cardiac Surgery associated Acute kidney injuryCritical Illness
Guowei Tu1,491 enrolled2 locationsNCT07418242
Recruiting

Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Cardiac surgery with cardiopulmonary bypass
Mayo Clinic100 enrolled1 locationNCT06895213
Recruiting
Phase 3

Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery

Post Operative PainBariatric SurgeryCardiac Surgery With Sternotomy
Icahn School of Medicine at Mount Sinai235 enrolled1 locationNCT07539623
Recruiting
Not Applicable

Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.

Congenital Heart Disease (CHD)Postoperative Respiratory DysfunctionPostoperative Recovery After Cardiac Surgery
University of Baghdad99 enrolled4 locationsNCT07405333
Recruiting

The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients

Antihypertensive AgentsCardiac SurgeryHemodynamics+2 more
Konya City Hospital160 enrolled1 locationNCT07541222
Recruiting
Phase 4

LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery

myocardial injury after non-cardiac surgeryAutonomic DysfunctionCardiovascular (CV) Risk+3 more
Insel Gruppe AG, University Hospital Bern114 enrolled1 locationNCT07168421
Recruiting
Phase 3

Evaluation of Analgesia for Cardiac Elective Surgery in Children

Pediatric Cardiac Surgery
Senthil Sadhasivam500 enrolled1 locationNCT06626035