RecruitingNot ApplicableNCT07543666

The ISAR InflEx Trial (Inflammation and Exercise)

Impact of Different Exercise Intensities and Durations on Systemic Inflammation - The ISAR InflEx Trial (Inflammation and Exercise) -

Sponsor

Department of Cardiology German Heart Center Munich TUM University Hospital

Enrollment

33 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Inflammation Obesity (Disorder)

Summary

A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria5

BMI 25.0 - 30.0 kg/m²
age 18 - 45 years
informed consent
no regular physical activity (≤1x/week of structured exercise)
willingness to strictly follow and adhere to the intervention protocol for the entire study

Exclusion Criteria4

any acute or chronic illness
pregnancy and breastfeeding
active smoking
Regular use of medication

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Interventions

PROCEDUREmoderate-intensity exercise

Guideline recommended 150 min/week of moderate-intensity aerobic physical exercise (40-50% VO2peak) on 5 days per week (30 min per session)

PROCEDUREvigorous-intensity exercise

Guideline recommended 75 min/week of vigorous-intensity physical exercise (70-80% VO2peak) on 5 days per week (15 min per session)

PROCEDUREshort bouts of maximal exercise

Maximal vigorous-intensity physical exercise for 1 minute twice per day (\>90% VO2peak) on 5 days per week (1 min per session, total of 2 min per day)