RecruitingNCT07547891

Shear Wave Elastography for Evaluation of Hydronephrosis in Pregnancy

Renal Cortical Stiffness Measured by Shear Wave Elastography for Evaluation of Hydronephrosis in Pregnancy: A Prospective Study


Sponsor

Beni-Suef University

Enrollment

250 participants

Start Date

Apr 7, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

Hydronephrosis is common during pregnancy and is often physiological; however, it may also result from true obstruction requiring intervention. Differentiating between physiological and obstructive hydronephrosis remains a clinical challenge using conventional ultrasound. This prospective observational study aims to evaluate the diagnostic accuracy of renal cortical stiffness measured by shear wave elastography (SWE) in differentiating obstructive from physiological hydronephrosis in pregnant women. Participants presenting with hydronephrosis will undergo clinical assessment, laboratory investigations, and ultrasound evaluation including SWE measurements. The diagnostic performance of SWE will be assessed using receiver operating characteristic (ROC) analysis, and optimal cut-off values will be determined. The study aims to provide a safe, non-invasive, and quantitative tool to improve diagnosis and guide management in pregnant patients with hydronephrosis.


Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria4

  • Pregnant women ≥12 weeks gestation with Loin Pain.
  • Sonographic evidence of hydronephrosis.
  • Age ≥18 years.
  • Provided informed consent

Exclusion Criteria5

  • Chronic kidney disease (CKD).
  • Congenital renal anomalies.
  • Pre-eclampsia
  • Poor acoustic window.
  • Contraindication to examination position.

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Interventions

DIAGNOSTIC_TESTShear Wave Elastography (SWE)

Shear wave elastography (SWE) is a non-invasive ultrasound-based imaging technique used to measure renal cortical stiffness. In this study, SWE is performed as a diagnostic assessment tool in pregnant women with hydronephrosis to evaluate its ability to differentiate between obstructive and physiological causes. No therapeutic intervention is applied.


Locations(1)

Beni Suef university hospital

Banī Suwayf, Beni Suef Governorate, Egypt

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NCT07547891


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