Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy in Vietnam
Efficacy of Controlled Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
National Children's Hospital, Vietnam
120 participants
Jun 10, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate the effectiveness of therapeutic hypothermia in neonates diagnosed with hypoxic-ischemic encephalopathy (HIE). The study focuses on assessing both short-term outcomes after treatment and long-term neurological outcomes following therapeutic hypothermia.
Eligibility
Inclusion Criteria7
- Neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) at the Neonatal Center, National Children's Hospital
- Gestational age ≥ 36 weeks
- Assessed using the modified Sarnat staging within the first 0-6 hours after birth
- Eligible for and/or treated with therapeutic hypothermia according to institutional protocol
- Underwent clinical and paraclinical monitoring during hospitalization
- Received brain magnetic resonance imaging (MRI) during the neonatal period (from 5 to 17 days of age)
- Availability of complete medical records for data collection and analysis
Exclusion Criteria3
- Presence of major congenital anomalies, particularly involving the central nervous system
- Absence of brain MRI during the study period
- Refusal of participation by parent(s) or legal guardian(s)
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Interventions
Therapeutic hypothermia will be administered to neonates with HIE according to the protocolized technical procedure developed and standardized in the study. The intervention is initiated in eligible neonates within 6 hours after birth and is performed with continuous clinical and neurologic monitoring as specified in the protocol.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07555652