Opportunistic Breast Cancer Screening Using Non-Contrast Chest CT
Artificial Intelligence-Assisted Opportunistic Screening for Breast Cancer Using Non-Contrast Chest CT: A Comparative Study With Mammography and/or Breast MRI
Fudan University
5,000 participants
May 6, 2026
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to evaluate the feasibility and effectiveness of using non-contrast chest computed tomography scans for opportunistic breast cancer screening, and to further compare its diagnostic performance with conventional imaging modalities, including mammography and/or breast magnetic resonance imaging.
Eligibility
Inclusion Criteria5
- Female patients who have undergone non-contrast chest CT examination;
- Participants included in the comparative analysis must have undergone at least one comparator imaging modality (mammography and/or breast MRI);
- If a breast lesion is detected, it must be confirmed by pathology or clinical follow-up at least 12 months;
- No prior systemic or local therapy before imaging examinations;
- Imaging data are complete and of sufficient quality for analysis.
Exclusion Criteria5
- History of other malignancies with potential impact on breast imaging interpretation;
- Participants with suspected malignant breast lesions but no confirmation;
- Prior radiotherapy, chemotherapy, or immunotherapy before imaging examinations;
- Imaging data that are incomplete, of poor quality, or contain significant artifacts preventing reliable analysis;
- Time interval between non-contrast chest CT and comparator imaging modalities exceeding three months, or with clinical events occurring between examinations that may alter lesion status.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07557654