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RecruitingPhase 1NCT07570082

Drug-Drug Interaction Study of Atumelnant in Healthy Participants

A Phase 1, Open-Label, Two-Cohort Study to Assess the Effect of a Strong CYP3A4 Inducer on the Pharmacokinetics of Atumelnant and the Effect of Atumelnant on the Pharmacokinetics of CYP3A4, P-gp, and MATE1/2-K Substrates in Healthy Participants

Sponsor

Crinetics Pharmaceuticals Inc.

Enrollment

46 participants

Start Date

May 6, 2026

Study Type

INTERVENTIONAL

Conditions

Healthy Volunteers

Summary

This study aims to evaluate the impact of strong CYP3A4 induction on the pharmacokinetics (PK) of atumelnant, as well as the effect of atumelnant on CYP3A4, P-gp, and MATE1/2-K substrates in healthy participants.

Eligibility

Min Age: 19 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Atumelnant, a drug called Carbamazepine, and others for people with healthy volunteers. The study is currently recruiting participants at 1 location. People eligible for this study include aged 19 Years to 55 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtumelnant

Atumelnant, tablets

DRUGCarbamazepine

CYP3A4 inducer

DRUGMidazolam

CYP3A4 substrate

DRUGDigoxin

P-gp substrate

DRUGMetformin

MATE1/2-K substrate

Locations(1)

Crinetics Study Site

Lincoln, Nebraska, United States

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NCT07570082

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