RecruitingNot ApplicableNCT07571330
Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.
Effectiveness of Upper Punctal Plug Occlusion in Patients With Dry Eye Disease With Previous Lower Punctal Occlusion.
Sponsor
Universidad Autonoma de Nuevo Leon
Enrollment
36 participants
Start Date
Feb 12, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.
Eligibility
Min Age: 18 Years
Inclusion Criteria7
- Patients of both sexes
- One or both eyes may be included
- Inferior lacrimal punctum occluded (with a punctal plug or cauterization), clinically sealed under slit-lamp examination
- Functional superior lacrimal punctum
- Aqueous-deficient dry eye (such as Sjögren's disease, graft-versus-host disease, or primary dry eye disease.)
- Age >18 years
- OSDI score >13 and one of the following signs: Tear film markers (Fluorescein tear break up-time <5, First non-invasive tear breakup time <10, Schirmer test without anesthesia <10 mm, Schirmer test with anesthesia <10 mm), Ocular surface markers (corneal staining >5 spots or conjunctival staining >9 spots).
Exclusion Criteria2
- Active ocular surface infection.
- Patients who are unwilling to participate or to provide written informed consent.
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Interventions
PROCEDUREPunctal plug occlusion
Superior lacrimal punctal occlusion with plug in patients with aqueous-deficient dry eye who have previously occlusion of the inferior lacrimal punctum.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07571330