RecruitingNot ApplicableNCT07583823
Elevated Rate Pacing of Cardiac Amyloidosis
Sponsor
University of Minnesota
Enrollment
10 participants
Start Date
Oct 10, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This study aims to better quantify the improvements in heart failure symptoms and exercise tolerance before and after the heart rate elevation in a cohort of 10 cardiac amyloidosis patients with preexisting pacemakers.
Eligibility
Min Age: 18 Years
Inclusion Criteria7
- Adults 18 and older
- Diagnosis of cardiac amyloidosis as indicated by the criteria set forth in guidelines such as in Kittleson et al: "2023 ACC Expert Consensus Decision Pathway on Comprehensive Multidisciplinary Care for the Patient With Cardiac Amyloidosis: A Report of the American College of Cardiology Solution Set Oversight Committee
- Implanted Cardiac Pacemaker (+/- Defibrillator)
- Pacemaker mode of AAI or DDD if in sinus rhythm, VVI acceptable if permanent atrial fibrillation
- Non-dilated left ventricle by echocardiography
- Ability to provide written consent
- English Speaking
Exclusion Criteria2
- Paced QRS duration of >150 ms (indicator for pacing mediated dyssynchrony)
- Dilated left ventricle
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Interventions
OTHERPacemaker Rate
CA clinic patients with pacemakers will receive a personalized pacing protocol individual to their height and left ventricular ejection fraction.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07583823
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