RecruitingNCT07586735

A Novel Conditioning Regimen for Haplo-HSCT in Older Patients With SAA

A Novel Conditioning Regimen for Haploidentical Hematopoietic Stem Cell Transplant in Patients Aged ≥ 40 Years Old With Severe Aplastic Anemia: a Multicenter, Single-arm, Observational Clinical Trial

Sponsor

Peking University People's Hospital

Enrollment

64 participants

Start Date

Jun 1, 2026

Study Type

OBSERVATIONAL

Conditions

Aplastic Anaemia Severe Aplastic Anemia Hematopoietic Cell Transplant

Summary

The goal of this prospective, multicenter, single arm observational study is to evaluate the efficacy and safety of the BFCA regimen in ≥ 40 years old SAA patients undergoing haplo-HSCT.

Eligibility

Min Age: 40 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called BFCA conditiong regimen for people with aplastic anaemia, hematopoietic cell transplant, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 40 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBFCA conditiong regimen

busulfan 0.8 mg/kg/6h (days -8 to -7), fludarabine 30mg/m2/day (days -6 to -2), cyclophosphamide 25 mg/kg/day (days -5 to -2) and antithymocyte globulin(ATG) 2.5 mg/kg/day (days -5 to -2).

Locations(1)

Peking Universtiy Peoples' Hospital

Beijing, Beijing Municipality, China

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NCT07586735

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