Pain Assessment During Rapid Sequence Induction
Nociception Assessment During Rapid Sequence Induction: A Prospective Observational Study of Practices and Complications - The NARSI Study
Centre Hospitalier Princesse Grace
150 participants
May 21, 2026
OBSERVATIONAL
Conditions
Summary
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception using the Analgesia Nociception Index (ANI) during this procedure. This monocentric prospective observational study aims to describe the impact of RSI on pain measured by ANI, and to explore early complications (desaturation, hypotension, regurgitation) and factors associated with pain and complications. 150 patients undergoing RSI in the visceral surgery operating room at CHPG Monaco will be analyzed.
Eligibility
Inclusion Criteria3
- Age >= 18 years
- Patient requiring tracheal intubation after rapid sequence induction in the visceral surgery operating room
- Pain monitoring by Analgesia Nociception Index (ANI) as part of general anesthesia
Exclusion Criteria2
- Patient with atrial fibrillation at the time of intubation following rapid sequence induction
- Patient on long-term beta-blocker therapy
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Interventions
Standard rapid sequence induction according to SFAR guidelines, with additional non-invasive ANI monitoring via cutaneous pectoral electrodes. No intervention beyond routine care; induction drug choice (hypnotic, opioid, neuromuscular blocker) at the discretion of the anesthesiologist.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07588165