RecruitingPhase 2NCT07595705
Gingival Hyperpigmentation Treatment
Gingival Hyperpigmentation Treatment With Injectable Vitamin C in Conjunction With Glutathione Versus The Conventional Surgical Depigmentation: A Randomized Controlled Clinical Trial
Sponsor
Cairo University
Enrollment
30 participants
Start Date
Aug 1, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel
Eligibility
Min Age: 18 Years
Inclusion Criteria10
- The selection criteria were done according to Gingival pigmentation index is as follows (Dummett and Bolden)10:
- Score0:absence of pigmentation
- Score1:spotsofbrowntoblackcolororpigments
- Score2:browntoblackpatchesbutnotdiffusepigmentation
- Score3:diffuse brown to black pigmentation,marginal,and attached.
- Patients who have Dummett and Bolden index score 1, 2, or 3 will be included in addition to the following criteria:
- above 18yrs
- systemically free
- physiologic gingival hyperpigmentation related to esthetic region
- well maintained oral hygiene and willing to undergo minor surgical procedures
Exclusion Criteria6
- systemic diseases associated with pathological hyperpigmentation or improper delayed wound healing (uncontrolled diabetes, autoimmune diseases, etc.)
- pregnant and lactating mothers
- usage of chlorhexidine or povidone iodine
- Local causes (smoking)
- periodontal diseases (plaque and non-plaque induced gingivitis or periodontitis)
- non compliant patients
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGVitamin c and glutathione
Vitamins c and glutathione injection that usually used for cosmetic skin care (whitening)
PROCEDURESurgical depigmentation
Removal of gingival pigmentation by scalpel
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07595705
Related Trials
Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia
NCT074146931 location
Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.
NCT074101561 location
Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation
NCT073593393 locations
Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC
NCT068964221 location
High - Dose Vitamin C Infusion Regimen Based on Pharmacokinetic Characteristics for Patients With Advanced Malignant Solid Tumors
NCT071210361 location