Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation
Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study
Al-Azhar University
20 participants
Mar 2, 2026
INTERVENTIONAL
Conditions
Summary
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
Eligibility
Inclusion Criteria4
- Systemically healthy patient of both genders aged from 18-45 years.
- Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.
- Good oral hygiene.
- Thick gingival phenotype.
Exclusion Criteria5
- Patient clinically diagnosed with periodontitis.
- Pregnant or lactating females.
- Patient with previous treatment of gingival hyperpigmentation.
- History of hypersensitivity to any study material.
- Patients who are active or previous smokers.
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Interventions
Surgical gingival depigmentation performed using the conventional scalpel technique. The pigmented gingival epithelium is surgically removed under local anesthesia to eliminate melanin pigmentation and improve gingival esthetics.
Coenzyme Q10 administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.
Vitamin C administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.
Coenzyme Q10 and vitamin c administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival repigmentation.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07677826